Results 61 to 70 of about 40,185 (314)

Organisational culture and trust as influences over the implementation of equity-oriented policy in two South African case study hospitals

open access: yesInternational Journal for Equity in Health, 2017
Background This paper uses the concepts of organisational culture and organisational trust to explore the implementation of equity-oriented policies – the Uniform Patient Fee Schedule (UPFS) and Patients’ Rights Charter (PRC) - in two South African ...
Ermin Erasmus   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The Art of Meaningful Universal Values

open access: yes, 2023
This article explores the relationship between individual and organisational values in order to create a positive performance outcome. Meaningful organisational cultures based on intrinsic values have been found to increase staff engagement and create a ...
Tungtakanpoung, M., Postoyeva, M.
core  

How to change organisational culture: Action research in a South African public sector primary care facility

open access: yesAfrican Journal of Primary Health Care & Family Medicine, 2016
Background: Organisational culture is a key factor in both patient and staff experience of the healthcare services. Patient satisfaction, staff engagement and performance are related to this experience.
Robert Mash   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Values as fixed and fluid: Negotiating the elasticity of core values. Kap. 11 [PDF]

open access: yes, 2020
This chapter explores how managers perform values work by negotiating organisational core values. By using an acute infection crisis in a Norwegian faith-based hospital as a case study, I examine how managers in two departments strategically evoke and ...
Stephen Sirris, Sirris, Stephen
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Knowledge creation and deployment in the small, but growing, enterprise and the psychological contract [PDF]

open access: yes, 2010
This paper contains an account of a small scale investigation into the usefulness of the concepts of the learning organisation and organisational learning when seeking to describe the processes of knowledge creation and deployment within the small, but ...
Tony Leach, Leach, Tony
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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