Results 131 to 140 of about 130,600,341 (310)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Project for an Agreement Between the League of Arab States and the Organization of African Unity

open access: yes, 1975
Council of Ministers Twenty-Fourth Ordinary Session Addis Ababa- February 1975In this project report, Arab states and the Organization of African of states entered into a formal dialogue aimed at strengthening political and economic cooperation amongst ...
Organization of African Unity
core  

Application for Subvention Submitted by the African Organization of Supreme Audit Institutions [PDF]

open access: yes, 1982
Council of Ministers Thirty-eighth Ordinary Session Addis Ababa, Ethiopia February 1982This is an application request from the African Organization of Supreme Audit Institutions to the General Secretariat of the OAU for its usual subvention to support ...
Organization of African Unity
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Organization of African Unity budget for the period 1 March, 1965 to 31 May, 1966

open access: yes, 1965
Summary of budget for the period 1st March, 1965 to 31st May, 1966 of the Organization of African ...
Organization of African Unity
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Application for Subvention for the Financial Year 1980/81 by the Organization of African Trade Union Unity

open access: yes, 1980
Council of Ministers Thirty-Fourth Ordinary Session, February 1980A report on the application for subvention from the Organization of African Unity by the Organization of African Trade Union Unity with highlights on its activities and it ...
Organization of African Unity
core  

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