African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent. [PDF]
Infect Agent Cancer, 2016 Ogunbiyi JO, Stefan DC, Rebbeck TR.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Validity and Reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 - Tagalog among Adult Filipinos with Differentiated Thyroid Cancer. [PDF]
J ASEAN Fed Endocr Soc, 2018 Bernardo DC, Li RJ, Jimeno C.
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Risk Assessment in Low-Grade Gliomas: An Analysis of the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) criteria. [PDF]
Oncol Ther, 2018 Lanese A, Franceschi E, Brandes AA.
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics. [PDF]
Ann Transl Med, 2016 Menis J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Partnership Among Peers: Lessons Learned From the Development of a Community Organization-Academic Research Training Program. [PDF]
Prog Community Health Partnersh, 2016 Jewett-Tennant J +6 more
europepmc +1 more source