Results 201 to 210 of about 2,136,041 (261)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Organization-discouraged or encouraged employee deviate behavior: a study of the typology and personal factors. [PDF]

Front Psychol
Li XF, Sheng CW, Chen MC.
europepmc   +1 more source

Insights from the young people who serve on youth advisory councils in Africa: a mixed-methods study. [PDF]

BMC Public Health
Gebrekristos LT, Pagán S, Albert I, Choonara S, Mensa-Kwao A, Jácome DI, Biermann O, Nagata JM, Li L, O'Sullivan M, Ezeh A, Baird S, Groves AK.   +12 more
europepmc   +1 more source

Cell identity competes with surface tension to determine stromal organization in tumor spheroids beyond the CAF shell paradigm. [PDF]

Proc Natl Acad Sci U S A
Wilhelm C.
europepmc   +1 more source

Organizing Collaborative Research

, 2015
openaire   +1 more source

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Ethics and Regulation in Organ Procurement Research

Progress in Transplantation, 2002
This article explores the role of ethics and regulation in human research conducted by organ procurement agencies; basic ethical principles for human research are outlined. Organ procurement agencies are not required to observe federal regulations; however, voluntary adherence will ensure that procurement research is conducted according to current ...
Terrence F, Ackerman, Rebecca P, Winsett
openaire   +2 more sources

Organizing entrepreneurship (research)

2014
The goal of this chapter is to offer some thoughts about the nature of the field of entrepreneurship, and particularly about the future of entrepreneurship scholarship. I begin with a recollection of a suggestion I made to students at doctoral seminars in the 1990s that 'all academic research on entrepreneurship could easily be read within a couple of ...
openaire   +2 more sources