Results 111 to 120 of about 11,408,167 (301)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Enabling Business Model Change: Evidence from High-Technology Firms

Journal of Entrepreneurship, Management and Innovation, 2015
Companies today face volatie environments, short product life cycles, and changing customer requirements, which is especially the case in high-technology filds.
Christiana Müller, Stefan Vorbach
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gestión de recursos humanos para la salud : informe de un Comité de Expertos de la OMS [se reunió en Ginebra del 3 al 9 de noviembre de 1987] [PDF]

, 1989
61 p.Sets out the conclusions and recommendations of an expert committee convened to consider ways to improve the management of the health workforce. Noting that personnel form the most expensive component of health services, the report concentrates on ...
WHO Expert Committee on Management of Human Resources for Health, World Health Organization   +1 more
core  

Implementing organization and management innovations in Swedish healthcare : Lessons from a comparison of 12 cases

, 2012
Purpose: The purpose of this paper is to compare the implementation of twelve different "organization and management innovations" (OMIs) in Swedish healthcare, to discover the generic and specific factors important for successful healthcare improvement ...
Tolf, Sara,, Andreen-Sachs, Magna,, Hansson, Johan I.,, Gustafsson, Helena,, Keller, Christina,, Mazzocato, Pamela,, Brommels, Mats,, Øvretveit, John,, Löfgren, Susanne,, Carlsson, Jan,   +9 more
core   +4 more sources

Scoping Ethical AI in Working Life: Lessons for the Nordic Model

Nordic Journal of Working Life Studies
The Nordic working life is characterized by high union density, flat organizations, and trust. In this context, ethical artificial intelligence (AI) implementation requires dialogue and collective decision-making between employers and employees.
Christoffer Larsson, Anna Launberg, Eva Lindell   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Infrastructure and social practices of street physical culture in Moscow

Здоровье мегаполиса
The purpose of this study is to examine the infrastructure and practices of using outdoor sports grounds. Materials and methods. Method of non-included standardized observation was used in the sociological study.
Ignat V. Bogdan, Mariya V. Gurylina, Darya P. Chistyakova   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source