Results 121 to 130 of about 6,480,619 (297)

Mental Frames and Organizational Decision-making: Facing the Challenges of Change [PDF]

Adjusting to the strategic, business and economic changes requires efficient decision-making procedures which can in turn be highly affected by the underlying mental frames that the leaders of the organization hold.
Lamprinakis, Lampros, Fulton, Murray E.
core  

An integrative model of clinical-ethical decision making

, 1991
The purpose of this paper is to propose a model of clinical-ethical decision making which will assist the health care professional to arrive at an ethically defensible judgment.
Grundstein-Amado, Rivka, Rivka Grundstein-Amado   +1 more
core   +1 more source

Organizational Pressure and Pilot Decision-Making in Adverse Weather: A Naturalistic Decision-Making Analysis of Helicopter Accidents

Journal of Aerospace Technology and Management
This paper aims to analyze helicopter accidents occurring in meteorological scenarios where flights should have been avoided, identifying patterns that influence pilots’ misjudgments.
Douglas Estevam Casale,  Rafaela Campos da Silva, Dante Ricardo Ambrosio, Mirian Kelly Miranda Drago, Moacyr Machado Cardoso Júnior, Luís Eduardo Vergueiro Loures da Costa   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Optimal Design of Fallible Organizations: Invariance of Optimal Decision Criterion and Uniqueness of Hierarchy and Polyarchy Structures [PDF]

We present a general framework to study the project selection problem in an organization of fallible decision-makers. We show that when the organizational size and the majority rule for project acceptance are optimized simultaneously, the optimal quality
Winston T H Koh
core  

Inter-organizational Negotiation and Intra-organizational Power in Shared Decision-making: Early agreements under codecision and their impact on the European Parliament and the Council of Ministers. IHS Political Science Series: 2004, No. 95 [PDF]

, 2004
In this article we argue that closer attention should be paid to the inter-organizational rules of decision-making and their implications for intra-organizational processes.
Farrell, Henry, Héritier, Adrienne.
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Passing the buck in the garbage can model of organizational choice [PDF]

We reconstruct Cohen, March and Olsen's Garbage Can model of organizational choice as an agent-based model. In the original model, the members of an organization can postpone decision-making.
Fioretti, Guido
core