ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang +13 more
wiley +1 more source
Cognitive Biases and Moral-Regulatory Mechanisms in White-Collar Crime: A Systematic Review and Bibliometric Mapping of Psychological Pathways to Corporate and Financial Misconduct. [PDF]
Dote-Pardo J +4 more
europepmc +1 more source
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho +9 more
wiley +1 more source
The Augmented Leader: Four Competencies for AI-Integrated Leadership Development in Higher Education. [PDF]
Lopez-Lopez D +3 more
europepmc +1 more source
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang +7 more
wiley +1 more source
Health System- and Payer-Level Decision-Making Processes Influencing the Adoption and Sustainability of Patient-Facing Digital Health Tools: Qualitative Study. [PDF]
Herzog M, Park LS, Quanbeck A.
europepmc +1 more source
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
Embracing the DIGNITY of Resident Relationships: A Case Study of the Decision-Making in Aging and Dementia for Autonomy (DIGNITY) Protocol. [PDF]
Behrens L +9 more
europepmc +1 more source
Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3
ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li +17 more
wiley +1 more source
The moderator effect of the family business protocol on the financial performance of born globals firms: A trajectories analysis. [PDF]
Escandon-Barbosa D, Salas-Paramo J.
europepmc +1 more source

