Results 51 to 60 of about 112,879 (262)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Qubahan Academic JournalDecision making is one of the important capability of managers in all organizations. This importance increases in Saudi Arabia due to the governance and structural reforms based on vision 2030.
Abdulrahman Eidhah Al Shamlan
doaj +1 more source
Revista Panamericana de Salud Pública, 2018 Objective. To analyze the value judgments behind cost–benefit tradeoffs made by health stakeholders in deciding whether or not to incorporate new health technologies and how they should be financed and allocated in limited-resource settings in Brazil ...
Luiz Santoro Neto +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The impact of perceived organizational cronyism on decision-making: The moderating role of ethical organizational culture [PDF]
Problems and Perspectives in ManagementOne of the primary responsibilities of managers is to make informed decisions that promote company progress and enhance performance. Unfortunately, not all managers adhere to appropriate decision-making standards.
Hamza Khraim
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The analysis of the capacity of the selected measures of decision-making models in companies
Copernican Journal of Finance & Accounting, 2015 The paper aims at the analysis of the information capacity of selected instruments of the assessment of decision-making models in the analyzed companies. In the paper there are presented the idea and concepts of decision-making models.
Helena Kościelniak +3 more
doaj +3 more sources
AI-Driven Decision-Making in the Egyptian Banking Sector: The Mediating Role of Decision-Making Efficiency [PDF]
المجلة العربية للإدارةThe purpose of this study is to assess the impact of artificial intelligence (AI) capabilities on strategic planning and execution in the Egyptian banking sector.
Amira Omar
doaj +1 more source