Results 101 to 110 of about 8,473,367 (245)
Journal of Multidisciplinary Healthcare, 2020 Heru Santoso Wahito Nugroho Midwifery Department, Poltekkes Kemenkes Surabaya, Surabaya, Jawa Timur, IndonesiaCorrespondence: Heru Santoso Wahito NugrohoPoltekkes Kemenkes Surabaya, Pucang Jajar Tengah 56, Surabaya, Jawa Timur 60282, IndonesiaTel +62 ...
Nugroho HSW
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A MODEL FOR ENTERPRISES’ ENVIRONMENTAL SCANNING [PDF]
Management & MarketingToday’s environment determines companies to use scanning activities in order to seize the opportunities and to avoid the threats. Individual factors and organizational factors influence the scanning behavior.
Tudor NISTORESCU, Cătălin Mihail BARBU
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Organizational Culture and Network Embeddedness [PDF]
A question that has been neglected in network research is where differences in network embeddedness come from.The network literature reveals that there are three key characteristics of embedded relationships: trust, open communication, and joint problem ...
Noorderhaven, N.G. +2 more
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Effects of Organizational Factors on Knowledge Sharing
Journal of Information Management and PracticesIn organizations, knowledge sharing is a major source of innovation, performance, success, and goal achievement. This review-based study aims to extract the determinants of knowledge sharing from previously conducted studies.
Imran Ghaffar Sulehri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Psicologia: Reflexão e Crítica, 2005 This paper aims at demonstrating, through a critical review of current literature, the role of justice in organization/worker relationships, and the fertility of justice research for widening the understanding of some relevant organizational phenomena ...
Eveline Maria Leal Assmar +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source