Results 111 to 120 of about 201,236 (218)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Impact of Intensive Care Unit Type and Organizational Factors on Mortality in Patients Transferred from Internal Medicine Services to the Intensive Care Unit: A Prospective Cohort Study. [PDF]

Healthcare (Basel)
Yüce Aktepe M, Çakın Ö, Yıldırım ÖE, Ceylan ÇMA, Çakın H.   +4 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

The cost of smile: how individual and organizational factors moderate the impact of emotional labor on work alienation via burnout. [PDF]

Front Psychol
Üngüren E, Tekin ÖA, Avsallı H.
europepmc   +1 more source

Healthcare Professionals' Resilience During the COVID-19 and Organizational Factors That Improve Individual Resilience: A Mixed-Method Study. [PDF]

Health Serv Insights, 2023
Simões de Almeida R, Costa A, Teixeira I, Trigueiro MJ, Dores AR, Marques A.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Provider and Organizational Factors Impacting Routine Cancer Screening Among Older Medicaid Enrollees. [PDF]

Health Serv Res
Corredor-Waldron A, Nguyen AM, Nova J, Ma Y, Cantor JC, Kinney AY, Tsui J.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Burnout in practice: A qualitative study of the impact of organizational factors on burnout and patient care among VA mental health providers. [PDF]

Qual Res Med Healthc
Harrod M, Takamine L, Abraham K, Ortolan V, Burgess J, Grau PP, Sripada R, Zivin K.   +7 more
europepmc   +1 more source

Organizational Factors Associated with Certified Nursing Assistants' Job Satisfaction during COVID-19. [PDF]

J Appl Gerontol, 2023
Bryant NS, Cimarolli VR, Falzarano F, Stone R.   +3 more
europepmc   +1 more source