Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Only recently have scholars begun to focus on individual difference factors which can affect responses to organizational change. One individual difference factor neglected by previous research that may have an influence on responses to change is value ...
Jon Welty Peachey, Jennifer Bruening
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
CONVENTION THEORY : IS THERE A FRENCH SCHOOL OF ORGANIZATIONAL INSTITUTIONALISM? [PDF]
This paper highlights overlap and differences between Convention Theory and New Organizational Institutionalism and thus states the strong case for profitable dialog. It shows how the former can facilitate new institutional approaches.
Bertrand Valiorgue, Thibault Daudigeos
core
Organizational Learning and Marketing Capability Development: A Study of Charity Retailing Operation of British Social Enterprises [PDF]
Social enterprise is a hybrid form of profit- and social benefit-seeking organization whereby traditional nonprofit organizations pursue both their social mission and business opportunities.
Gordon Liu +5 more
core +1 more source
The Impact of Innovation-oriented Organizational Climate on Employee’s Creative Behavior: A Case Study in Poland [PDF]
Innovation serves as a crucial strategy for enterprises navigating complex and dynamic environments. Despite the acknowledged significance of this, the influence of an organization’s innovation environment on employees’ innovative behavior remains ...
Khaled Mohammed Al-Qahtani
doaj +1 more source
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley +1 more source
Inside the hybrid organization: An organizational level view of responses to conflicting institutional demands [PDF]
This paper explores organizational responses to conflicting institutional demands. An inductive comparative case study of four social enterprises that scaled their organization while embedded in competing social welfare and commercial logics suggests ...
Anne-Claire Pache, Filipe Santos
core
Deconstructing resistance to organizational change – A social representation theory approach
Purpose - Social representation theory (SRT) is a growing theory in social psychology research. SRT is about how individuals co-construct representations of various objects in different social settings.
Andersén, Jim +5 more
core +1 more source
The Concept of Communities of Practice on the Example of IT Sector
Background: A growing interest in the concept of communities of practice (CoP) has been recently observed in several academic fields. They include organizational studies (the topics of knowledge management and organizational learning in particular) and ...
Sztangret Izabela
doaj +1 more source

