Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2020 Background: Organizational health is a competitive advantage and an important factor with regard to the effectiveness of hospitals. Therefore, this study was conducted to investigate the relationship between organizational health and the degree of ...
Yadollah Hamidi +3 more
doaj
Knowledge management and communities of practice in the private sector: lessons for modernising the National Health Service in England and Wales [PDF]
, 2002 The National Health Service (NHS) in England and Wales has embarked upon a radical and farreaching programme of change and reform. However, to date the results of organizational quality and service improvement initiatives in the public sector have been ...
Bate, SP, Robert, G
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
PENGARUH IKLIM ORGANISASI DAN PENERAPAN KESELAMATAN DAN KESEHATAN KERJA (K3) TERHADAP PRODUKTIVITAS KERJA KARYAWAN PADA PROSES PRODUKSI DI PT BERKAT GANDA SENTOSA [PDF]
The purpose of this study is to determine the influence of organizational climate and the application of occupational safety and health on employee work productivity in the production process at PT. Berkat Ganda Sentosa partially and simultaneously. This
Mufidah, Putri Indah
core
Editorial Essay: Introduction to a Special Issue on Work and Employment Relations in Health Care [PDF]
, 2016 [Excerpt] This special issue of the ILR Review is designed to showcase the central role that work organization and employment relations play in shaping important outcomes such as the quality of care and organizational performance.
Avgar, Ariel C +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Satisfied Workers, Retained Workers: Effects of Work and Work Environment on Homecare Workers' Job Satisfaction, Stress, Physical Health, and Retention [PDF]
The goal of this project was to assist health system managers and policy makers develop policies and strategies to recruit and retain human resources in the homecare sector and have a satisfied, healthy workforce.
Isik U. Zeytinoglu, Margaret Denton
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source