Results 121 to 130 of about 319,651 (317)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
This paper examines the dynamic and multi-level relationship between organization and innovation from three different but interdependent perspectives: a) the relationship between organizational structural forms and innovativeness; b) innovation as a ...
Lam, Alice
core
Motivating Organizational Search [PDF]
This paper investigates the value of high-powered incentives for motivating search for novelty in business organizations. While organizational search critically depends on the individual efforts of employees, motivating search effort is challenged by ...
Nils Stieglitz, Oliver Baumann
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Passing the buck in the garbage can model of organizational choice
We reconstruct Cohen, March and Olsen's Garbage Can model of organizational choice as an agent-based model. In the original model, the members of an organization can postpone decision-making.
Fioretti, Guido
core
The improbable commitment: organizational commitment amongst South African knowledge workers [PDF]
Knowledge workers, who typically enjoy global labour mobility, are considered critical to economic growth in developing countries. The purpose of this dissertation was to examine the organizational commitment of South African knowledge workers, a ...
Bagraim, Jeffrey
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Organizational resilience and culture: A model for information technology service management (ITSM)
, 2012 Organizational change and organizational culture have been studied and written about by many authors, most notably by Edgar Schein (1990, 1992), and are named as critical components of organizational maturity through such industry standards as The ...
Granito, Francis A.
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Perceived organizational support, organizational cynicism and employee well-being
, 2014 The present study examined how an employee’s perception of their employing organization can impact his or her thoughts, feelings and behaviors. This study examined cognitive, affective and behavioral organizational cynicism in relation to perceived ...
Peplinski, Marin Sara
core