Results 61 to 70 of about 319,651 (317)

Modeling Organizational Architectural Styles in UML [PDF]

, 2003
Today's information systems operate within a dynamic, organizational context and consequently require flexible architectures to ensure that they remain operational and useful. The Tropos software development methodology is founded on the premise that social and intentional concepts (such as those of actor and goal) can be used throughout the ...
J. Castro, C. Silva, Mylopoulos, Ioannis
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Lifelong Learners Influencing Organizational Change

Studies in Business and Economics, 2018
Organizational change occurs in every organization that deals with growth and transition. Organizational leaders develop a commitment to lifelong learning throughout their careers.
Caves Lonzo
doaj   +1 more source

RATIONAL SUPPLY OF PRODUCTS TO ENTITIES OF ENTREPRENEURIAL ACTIVITY IN METROPOLIS

Вестник Российского экономического университета имени Г. В. Плеханова, 2017
The article researches the problem of truck transport service in big cities, for example Moscow. The work of transport companies which effect carriage is not coordinated or controlled and it can hinder passenger traffic, as well as movement of ...
Vladimir I. Stepanov, Olga V. Rykalina, Irina V. Sharova   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Chronic viral hepatitis and primary liver cancer in the republic of Sakha (Yakutia)

Журнал инфектологии, 2019
Study objective: identification of risk factors for the formation of cirrhosis and PLC in patients with chronic hepatitis B, C and D to develop a personalized, approach in treatment and prevention, of complications.Materials and. methods.
S. S. Sleptsova, S. S. Sleptsov, M. N. Andreev, M. E. Ignatieva, L. I. Budatsyrenova   +4 more
doaj   +1 more source

Extra-role behavior improvement model: Organizational learning culture, organizational trust, and organizational justice approach

International Journal of Engineering Business Management, 2020
One form of employee integrity can be seen from his desire to perform extra-role behavior. The purpose of this study is to analyze the influence of Organizational Trust to Organizational Learning Culture directly or indirectly through Organizational ...
Wahda, Mursalim, Fauziah, Asty
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source