Results 121 to 130 of about 1,142,978 (287)

Do firms rely on sources of information for organizational innovation? [PDF]

open access: yes
The growing literature on knowledge and information has focused on the impact of information sources on technological innovation. Our objective was to explore the use made by firms of internal and external (market, research and generally available ...
MOTHE Caroline, NGUYEN Thi Thuc Uyen
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Changing organizational culture in terms of information and communications technologies [PDF]

open access: yes
Organizational change can be considered a genuine moment of evolution and development of the entire organization and decision of change is closely related to the company's mission, the objectives that wish to achieve in order to ensure their competitive ...
Daniel Boldureanu   +3 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Sleep Breathing Disorders in the COVID-19 Era: Italian Thoracic Society Organizational Models for a Correct Approach to Diagnosis and Treatment. [PDF]

open access: yesRespiration, 2020
Insalaco G   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Emergence of Non-Traditional Cooperative Structures: Public and Private Policy Issues [PDF]

open access: yes
This paper examines new agricultural cooperative organizational models from an ownership rights perspective. We argue that new cooperative organizational models differ in the way ownership rights are assigned to the economic agents tied contractually to ...
Chaddad, Fabio Ribas, Cook, Michael L.
core   +1 more source

The organization as an information system: signposts for new investigations [PDF]

open access: yes, 1999
This paper focuses on the question of how industry should adapt to today's information environment. It is proposed that businesses should look to long-standing organizations such as the church and government for an appropriate information model.
Barlow, HA, Burke, ME
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Collaborating for Gender Equity in Christian Education

open access: yes, 2020
This essay addresses the importance of teachers promoting gender equity. It explores potential causes for gender discrimination in Christian institutions including double standards, unequal representation, organizational culture and similarity attraction.
Castellon, Adrienne R., Sowerby, Stacy
core  

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