Results 151 to 160 of about 1,142,978 (287)

The Impact of Organizational Structure and Lending Technology on Banking Competition [PDF]

Recent theoretical models argue that a bank’s organizational structure reflects its lending technology. A hierarchically organized bank will employ mainly hard information, whereas a decentralized bank will rely more on soft information.
Degryse, H.A., Laeven, L., Ongena, S.
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Integrated Hospital-Territory Organizational Models and the Role of Family and Community Nurses in the Management of Chronic Conditions: A Scoping Review. [PDF]

Medicina (Kaunas)
Azzellino G, Vagnarelli P, Passamonti M, Mengoli L, Ginaldi L, De Martinis M.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Ligurian Experience in the Management of Lung Cancer: Organizational Models and New Perspectives. [PDF]

Healthcare (Basel)
Amicizia D, Marchini F, Pronzato P, Paoli G, Genova C, Allegretti S, Ansaldi F.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Organizational models and patient-reported outcomes for palliative care across five tertiary hospitals in Nigeria: An environmental scan. [PDF]

PLOS Glob Public Health
Ogbenna AA, Caputo M, Onyeka TC, Ohanete DO, Johnson LS, Sam-Agudu NA, Obiezu-Umeh C, Akodu B, Drane D, Evans CT, Akinwale MO, Ndukwu GU, Kolawole IK, Ayilara SA, Eke GK, Akinsete AM, Ogunseitan A, Doobay-Persaud A.   +17 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

TABLET TOSCANA to Develop Innovative Organizational Models for Tele-Rehabilitation in Subjects with Congenital and Acquired Developmental Disabilities: A Wait-List Control Group Trial Protocol. [PDF]

J Clin Med
Barzacchi V, Mangani G, Del Lucchese B, Menici V, Bombonato C, Beani E, Biagioni E, Palla I, Posteraro F, Trieste L, Turchetti G, Sgandurra G, Cioni G, On Behalf Of Tablet Toscana Consortium.   +13 more
europepmc   +1 more source

Explaining the structure of inter-organizational networks using exponential random graph models: does proximity matter? [PDF]

A key question raised in recent years is which factors determine the structure of inter-organizational networks. While the focus has primarily been on different forms of proximity between organizations, which are determinants at the dyad level, recently ...
Matte Hartog, Tom Broekel
core