Results 151 to 160 of about 1,154,495 (307)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Health economic analysis of organizational models for breast cancer surgery: a bottom-up micro-costing and cost-minimization approach. [PDF]

Health Econ Rev
Eriksson J, Meili KW, Lindholm L, Appelblad M, Sund M.   +4 more
europepmc   +1 more source

THE ORGANIZATIONAL KNOWLEDGE DYNAMICS (OKD) MODEL. CASE STUDY VODAFONE ROMANIA [PDF]

According to the new economic models, knowledge has to be incorporated in production functions as a key factor. Therefore, in the new knowledge based economy the main challenge is to develop, combine and integrate the knowledge of thousands of employees ...
Constantin BRĂTIANU, Ivona ORZEA
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Integrated Hospital-Territory Organizational Models and the Role of Family and Community Nurses in the Management of Chronic Conditions: A Scoping Review. [PDF]

Medicina (Kaunas)
Azzellino G, Vagnarelli P, Passamonti M, Mengoli L, Ginaldi L, De Martinis M.   +5 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The Ligurian Experience in the Management of Lung Cancer: Organizational Models and New Perspectives. [PDF]

Healthcare (Basel)
Amicizia D, Marchini F, Pronzato P, Paoli G, Genova C, Allegretti S, Ansaldi F.   +6 more
europepmc   +1 more source

Organizational knowledge creation [PDF]

The purpose of this paper is to present an overview of the state-ofthe- art in organizational knowledge creation, a field of research that is expanding almost exponentially.
Constantin BRATIANU, Ivona ORZEA
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source