Results 41 to 50 of about 1,675,548 (287)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mainstreaming food systems resilience into health resilience [PDF]

, 2021
This STG Resilience Paper is part of the Commission Research Report and Interim Progress Report (June 2021) published by Reform for Resilience.• Food production, distribution and consumption is a fundamental determinant of health resilience.
TAGLIACOZZO, Serena, PISACANE, Lucio, CONTI, Mauro, CORRADO, Alessandra   +3 more
core   +1 more source

THE IMPACT OF DIGITAL TRANSFORMATION ON ORGANIZATIONAL RESILIENCE AND ECONOMIC PERFORMANCE

Farabi Journal of Social Sciences
Purpose. This study develops and empirically tests an integrated model explaining how digital transformation enhances economic performance and organizational resilience through the mediating roles of digital transformation strategy, organizational ...
Valeriya Lis, Shynggys Nurgazy, Zaneta Simanaviciene   +2 more
doaj   +1 more source

Research on the Resilience Enhancement Path of Technology-Based SMEs Using Dynamic Fuzzy Cognitive Maps—Organizational Context and the Employee Loyalty Perspective

IEEE Access, 2023
Technology-based small and medium enterprises (SMEs) represent an important organizational aspect of technological innovation and economic growth. The complex and turbulent operating environment resulting from COVID-19 is a fatal threat to the survival ...
Teng Ma, Kexin Zhao
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Boundary object or bridging concept? A citation network analysis of resilience [PDF]

, 2015
Many recent studies observe the increasing importance, influence, and analysis of resilience as a concept to understand the capacity of a system or individual to respond to change. The term has achieved prominence in diverse scientific fields, as well as
Brown, Katriana, Denis Hellebrandt, Katrina Brown, Jacopo A. Baggio, Baggio, Jacopo A., Hellebrandt, Denis   +5 more
core   +1 more source

ORGANIZATIONAL RESILIENCE AS A MEDIATOR BETWEEN INDIVIDUAL AND GROUP RESILIENCE AND ORGANIZATIONAL PERFORMANCE: EVIDENCE FROM THE BALI REGIONAL OFFICE OF THE DIRECTORATE GENERAL OF TAXES

Indonesian Interdisciplinary Journal of Sharia Economics
This study examines the role of organizational resilience in mediating the influence of individual resilience and group resilience on organizational performance at the Bali Regional Office of the Directorate General of Taxes.
I Nengah Brate, Komang Krisna Heryanda, M. Rudi Irwansyah   +2 more
doaj   +1 more source

Resilience of staff and organization in a teaching hospital during the Corona pandemic [PDF]

Salāmat-i kār-i Īrān, 2023
Background and aims: The aim of this study was to evaluate the organizational and individual resilience of the staff of an educational and medical center affiliated to Gonabad University of Medical Sciences in the Corona pandemic.
Vajihe Armanmehr, Aliakbar Majdi, Abdoljavad Khajavi, Masumeh Amiri Delui, Mohammadhossein Esmailzadeh   +4 more
doaj