Results 111 to 120 of about 8,439,150 (298)

Organizational Change and the Concept of Structure

, 1971
Organizational structure is proposed to be viewed best as task structure, i.e., the patterned arrangements of task roles required in producing desired organizational outputs. The fundamental basis of task structure is underlying core technologies.
Stallings, Robert A.
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Challenges of the organizational structure of county health network in Iran: findings from a qualitative study. [PDF]

BMC Health Serv Res, 2022
Ghorrabi AT, Kakemam E, Moradi-Joo E, Dehcheshmeh NF.   +3 more
europepmc   +1 more source

Distance, Bank Organizational Structure and Credit [PDF]

We survey the extant literature on the effects of both a bank’s organizational structure and the physical distance separating it from the lender on lending decisions.
Cerqueiro, G.M., Degryse, H.A., Ongena, S.   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Networked Organizational Structure of Enterprise Information Security Management Based on Digital Transformation and Genetic Algorithm. [PDF]

Front Public Health, 2022
Di Z, Liu Y, Li S.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Organize Yapılar Üzerindeki Hâkimiyette Dolaylı Faillik Kurumunun Haksızlık Teorisi Yardımıyla Gerekçelendirilmesi

Türk-Alman Üniversitesi Hukuk Fakültesi Dergisi
Organize güç ilişkisine dayalı bir yapı içerisinde arkaplandaki kişinin tam sorumlu olan doğrudan failin işlediği suçtan dolayı dolaylı fail olarak cezalandırılması gerektiği görüşünün literatürde en yaygın gerekçesini oluşturan organizasyona egemenlik ...
Abdullah Yıldız
doaj   +1 more source

Organizational Structure Change and Hybridity: Enhancing Uncertainty as a Response to Competing and Changing Institutional Logics. [PDF]

Front Psychol, 2022
Liu L, Zhang C.
europepmc   +1 more source

How knowledge management mediates the relationship between environment and organizational structure.

, 2012
[[abstract]]Literature examining how knowledge management (KM) capability helps organizational structures cope with uncertainty is limited. Thus, this study builds and tests an integrated model to investigate the relationship among environmental ...
莊淑惠;Chuang, Shu-Hui;Chechen Liao;Pui-Lai To
core