Results 91 to 100 of about 2,770,354 (303)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The Organizational Transformation of Artificial Intelligence in Smart Cities: An Urban Artificial Intelligence Governance Maturity Model

Urban Science
The transformative potential of Artificial Intelligence (AI) in urban management is severely constrained by pervasive systemic fragmentation. While AI applications demonstrate high efficacy within isolated domains, they rarely achieve the cross-domain ...
Omar Alrasbi, Samuel T. Ariaratnam
doaj   +1 more source

Spiritual Leadership as a Paradigm for Organizational Transformation and Recovery from Extended Work Hours Cultures

, 2009
spiritual leadership, workaholism, organizational transformation, organizational culture,
Louis Fry, Melanie Cohen, Melanie P. Cohen, Louis W. Fry   +3 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Relationship Between Culture And Readiness To Accept Transformation In Single-Specialty Hospitals In Tehran

پیاورد سلامت, 2014
Background and Aim: Readiness to face changes and transformation in health fields is one of the main factors in health organizations’ success. The main purpose of the present study was to determine the relation between culture and readiness to accept ...
Hasan Abolghasem Gorji, Heshmatollah Asadi, Masoud Roudbari, Ahmad Barati Marnani, Mojtaba Hasoumi, Mohammad Mohseni   +5 more
doaj  

Organizational transformation for greater sustainability impact: recent changes in a scientific research infrastructure in Europe. [PDF]

Landsc Ecol, 2023
Holzer JM, Orenstein DE.
europepmc   +1 more source

Conceptual Provisions of Strategic Management of Organizational Transformation [PDF]

, 2016
Запропоновано концептуальні положення стратегічного управління організаційними трансформаціями. Закладено теоретичні основи розробки та впровадження організаційних перетворень.Conceptual provisions of strategic management of organizational transformation
Гордієнко, Лариса Ю., Gordiienko, Larysa   +1 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Firm Digitalization and Corporate Performance: The Moderating Effects of Organizational Capital

, 2023
This thesis examines the interplay between digital transformation and corporate performance with a special emphasis on the moderating effect of organizational capital.
Zareie, Mobina
core