Results 81 to 90 of about 2,770,354 (303)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Clinical Organizational Science: an integrative framework for structural intervention in complex organizations

Frontiers in Psychology
Organizations frequently fail to sustain transformation despite substantial investment in leadership development, cultural change programs, and structural redesign. Existing frameworks tend to treat organizational stability as passive inertia rather than
Makoto Yamanaka, Masaya Nakamori
doaj   +1 more source

A Model for Investigating the Role of Organizational Development Agents (OD Agents) in Reinforcement Of Organizational Development Flow [PDF]

مطالعات مدیریت بهبود و تحول
Developing the characteristics of "organizational development agents" and promoting them is one of the topics that has been less studied in the field of management, and media organizations have not been exempted from it.
mohammad saeid taslimi, آمنه kalateh Aghamohammadi, manouchehr ansari, taher roshandel   +3 more
doaj   +1 more source

Organizational Innovation [PDF]

This paper examines the dynamic and multi-level relationship between organization and innovation from three different but interdependent perspectives: a) the relationship between organizational structural forms and innovativeness; b) innovation as a ...
Lam, Alice
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Redefining Project Management: Embracing Value Delivery Offices for Enhanced Organizational Performance

Buildings
This paper explores the transition from traditional Project Management Offices (PMOs) to Value Delivery Offices (VDOs), marking a shift from a process-centric to a value-centric approach in project management. Utilizing a mixed-methods research approach,
Saeed Moghaddasi, Kambiz Kordani, Hadi Sarvari, Amirreza Rashidi   +3 more
doaj   +1 more source

Leading organizational transformation: an action research study [PDF]

, 2017
Purpose – This study addresses a specific gap in the literature that centers on individual perspective of leadership within the context of organizational transformation.
Stefano Cirella, Abraham Baruch (Rami) Shani, Canterino, Filomena, Cirella, Stefano, S. Cirella, Cirella, S, Shani, R, F. Canterino, Canterino, F, A. B. Shani, Filomena Canterino, Shani, Abraham Baruch (Rami)   +11 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source