Results 111 to 120 of about 12,146,452 (311)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Criminal Associations: Insights into the Concept, Types, and Challenges for Legislative Improvements to Combat Them

Ученые записки Казанского университета: Серия Гуманитарные науки
This article suggests improvements to the criminal law measures against organized crime. The terminology and conceptual framework of criminal groups were analyzed using various methods, such as dialectical, comparative-legal, system-structural, and ...
I. Yu. Kufelkina
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Renormalization group analysis of a continuous model with self-organized criticality: Effects of randomly moving environment

Nuclear Physics B
We study a strongly anisotropic self-organized critical system coupled to an isotropic random fluid environment. The former is described by a continuous (coarse-grained) model due to Hwa and Kardar.
N.V. Antonov, P.I. Kakin, N.M. Lebedev, A.Yu. Luchin   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Organized Crime, Corruption and Punishment [PDF]

We analyze an oligopoly model in which differentiated criminal organizations globally compete on criminal activities and engage in local corruption to avoid punishment.
Verdier, Thierry, Kugler, Maurice, Zenou, Yves   +2 more
core  

Features of cardiovascular risk in men and women of an organized group

Известия высших учебных заведений. Поволжский регион: Медицинские науки
Background. Chronic non-infectious diseases, primarily of the cardiovascular system, preserving leading positions among the causes of disability and mortality of the population in the world. The aim is to study individual factors of cardiovascular risk
Yu.A. Tomashevskaya, I.V. Avdeeva, P.M. Vasileva, E.I. Serikova, L.I. Salyamova   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Clinical research of organized stroke care model with integrated Chinese traditional and Western medicine in primary hospital

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To investigate the clinical effect of the organized stroke care model assisted with Chinese traditional medicine and acupuncture treatment for recovery in primary hospital.
Zhengbin PEI, Jinsheng ZHU, Rongbin HE, Zhilian PENG, Ansen YANG, Xuefeng ZHANG, Xin CHEN, Guofeng YU   +7 more
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source