Results 61 to 70 of about 15,358,698 (360)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Extraction of spatial genetic characteristics and analysis of 1930s Korean Urban Hanok based on application of space syntax

Journal of Asian Architecture and Building Engineering, 2022
This paper presents an analysis of an Urban Hanok (improved Korean traditional housing), created in the process of Seoul’s urbanization since the 1930s as anew housing type from traditional Hanoks, using aspace syntax methodology to uncover the ...
Jungmin Kim, Dongyun Kwak
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Sharing Our Story to Build Our Future: A Case Study of Evaluating a Partnership for Co‐Produced Research in Southeast Alaska

Community Science
The goal of this paper is to demonstrate the value of incorporating evaluation into the process of co‐produced research in pursuit of climate services. We aim to spur interest in and expand the use of evaluation throughout the climate change and climate ...
E. Figus, S. Friday, J. O’Connor, J. Jeet Koot Saak McDonald, C. James, S. F. Trainor, M. H. C. Rudolf, N. O’Connor   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

COMBATING ORGANIZED CRIME IN UKRAINE: CURRENT PROBLEMS AND POSSIBLE SOLUTIONS

Стратегічна панорама
This article presents the findings of a state-of-the-art analysis of Ukrainian legislation in the field of combating organized crime. The authors focus on specific features of meeting Ukraine’s obligations under the United Nations Convention against ...
Олександр Володимирович Шамара, Володимир Володимирович Комашко   +1 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group

The Journal of Nutrition, Health & Aging, 2013
The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons.
E. Kelaiditi, Matteo Cesari, Matteo Cesari, M. Canevelli, G. A. Kan, P. Ousset, S. Gillette‐Guyonnet, P. Ritz, F. Duveau, M. Soto, V. Provencher, F. Nourhashemi, A. Salvá, P. Robert, S. Andrieu, Y. Rolland, J. Touchon, J. Fitten, B. Vellas, B. Vellas   +19 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

CRIMINAL TERRORIST GROUP IN THE NEW CRIMINAL LEGISLATION OF ROMANIA [PDF]

Challenges of the Knowledge Society, 2016
In the Romanian criminal law, there is a specialized regulation that defines criminal terrorist group, as variant of plurality of offenders. The present study presents this kind of criminal group by identifying the elements of differentiation compared to
Mirela GORUNESCU
doaj