Results 121 to 130 of about 415,503 (309)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Organizing and Organizations: An Introduction [PDF]
Journal of the Operational Research Society, 2002 openaire +1 more source
Organizing Education by Drawing on Organizational Studies
This study explores how scholars researching organizations and organizing processes can use and exploit their knowledge not only in terms of course contents, but also in organizing and managing students' learning activity.A design-oriented research ...
Romme, A.G.L.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Curbing domestic violence: instantiating C-K theory with formal concept analysis and emergent self organizing maps. [PDF]
In this paper we propose a human-centered process for knowledge discovery from unstructured text that makes use of Formal Concept Analysis and Emergent Self Organizing Maps.
Elzinga, Paul +3 more
core
On_Culture, 2016 This article explores the significance of materiality and non- or other-human, especially the role of body and embodiment in relation to intra- and inter-practices in organizations and their culture from a phenomenological perspective and cross ...
Wendelin M. Küpers
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Self-Organizing Genetic Algorithm for Multiple Sequence Alignment
, 2011 Genetic algorithm (GA) used to solve the optimization problem is self-organized and applied to Multiple Sequence Alignment (MSA), an essential process in molecular sequence analysis.
Dr. Amouda Nizam, Kuppuswami Subburaya
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source