Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays
bioRxiv, 2021 Spatially resolved transcriptomic technologies are promising tools to study cell fate decisions in a physical microenvironment, which is fundamental for enhancing our knowledge of mammalian development.
Ao Chen +58 more
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A single-cell transcriptome atlas profiles early organogenesis in human embryos
Nature Cell Biology, 2023 Xu et al. provide a single-cell transcriptomic atlas of 4–6 week human embryos, thereby profiling early human organogenesis. The early window of human embryogenesis is largely a black box for developmental biologists.
Yichi Xu +9 more
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Human brain organogenesis: Toward a cellular understanding of development and disease.
Cell, 2021 The construction of the human nervous system is a distinctly complex although highly regulated process. Human tissue inaccessibility has impeded a molecular understanding of the developmental specializations from which our unique cognitive capacities ...
Kevin W. Kelley, S. Pașca
semanticscholar +1 more source
Cytokinins – regulators of de novo shoot organogenesis
Frontiers in Plant Science, 2023 Plants, unlike animals, possess a unique developmental plasticity, that allows them to adapt to changing environmental conditions. A fundamental aspect of this plasticity is their ability to undergo postembryonic de novo organogenesis.
Ján Šmeringai +2 more
semanticscholar +1 more source
Embryo model completes gastrulation to neurulation and organogenesis
Nature, 2022 Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1–5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembryonic ...
G. Amadei +14 more
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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Nature Biotechnology, 2021 Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches mostly rely on dissociating cells from tissues, thereby losing the crucial spatial context of regulatory processes. Here, we
T. Lohoff +19 more
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Primate gastrulation and early organogenesis at single-cell resolution
Nature, 2022 Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but ...
Jinglei Zhai +16 more
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A spatiotemporal atlas of organogenesis in the development of orchid flowers
Nucleic Acids Research, 2022 Development of floral organs exhibits complex molecular mechanisms involving the co-regulation of many genes specialized and precisely functioning in various tissues and developing stages.
Chang Liu +7 more
semanticscholar +1 more source
SOX9 in organogenesis: shared and unique transcriptional functions
Cellular and Molecular Life Sciences, 2022 The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and nervous system.
Zhenhua Ming +3 more
semanticscholar +1 more source
The single cell transcriptional landscape of mammalian organogenesis
Nature, 2019 Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of the three germ layers transform into an embryo that includes most of the major internal and external organs. Here we investigate the transcriptional dynamics of mouse
Junyue Cao +11 more
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