Results 1 to 10 of about 91,856 (332)
Primate gastrulation and early organogenesis at single-cell resolution
Nature, 2022 Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but ...
Jun Wu, Fan Guo, Jinglei Zhai
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A spatiotemporal atlas of organogenesis in the development of orchid flowers
Nucleic Acids Research, 2022 Development of floral organs exhibits complex molecular mechanisms involving the co-regulation of many genes specialized and precisely functioning in various tissues and developing stages.
Ji Qi, Yamao Chen, Chunce Guo
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Tumor Necrosis Factor Alpha Signaling and Organogenesis
Frontiers in Cell and Developmental Biology, 2021 Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Xuewen Xu, Hui Gu
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Immunity, 2018 &NA; Thymus development is critical to the adaptive immune system, yet a comprehensive transcriptional framework capturing thymus organogenesis at single‐cell resolution is still needed.
Eric Kernfeld, René Maehr
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Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
Cell Stem Cell, 2017 Atsuhiro Taguchi +1 more
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Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays
bioRxiv, 2021 Spatially resolved transcriptomic technologies are promising tools to study cell fate decisions in a physical microenvironment, which is fundamental for enhancing our knowledge of mammalian development.
Ao Chen +68 more
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A single-cell transcriptome atlas profiles early organogenesis in human embryos
Nature Cell Biology, 2023 Xu et al. provide a single-cell transcriptomic atlas of 4–6 week human embryos, thereby profiling early human organogenesis. The early window of human embryogenesis is largely a black box for developmental biologists.
Yichi Xu +9 more
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Cytokinins – regulators of de novo shoot organogenesis
Frontiers in Plant Science, 2023 Plants, unlike animals, possess a unique developmental plasticity, that allows them to adapt to changing environmental conditions. A fundamental aspect of this plasticity is their ability to undergo postembryonic de novo organogenesis.
Ján Šmeringai +2 more
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Toxics, 2023 Persistent organic pollutants (POPs) are posing major environmental and health threats due to their stability, ubiquity, and bioaccumulation. Most of the numerous studies of these compounds deal with single chemicals, although real exposures always ...
Gustavo Guerrero-Limón +4 more
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Integration of spatial and single cell transcriptomic data elucidates mouse organogenesis
Nature Biotechnology, 2021 Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches mostly rely on dissociating cells from tissues, thereby losing the crucial spatial context of regulatory processes. Here, we
T. Lohoff +19 more
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