Results 31 to 40 of about 66,436 (284)

The Effect of Coculture with Nonparenchymal Cells on Porcine Hepatocyte Function

Cell Transplantation, 2001
Porcine hepatocytes are currently being investigated as a therapy for patients suffering from acute liver failure. Incorporating hepatocytes in an extracorporeal device that would stabilize a patient until transplantation or recovery could dramatically ...
Paul G. Gregory, Christopher K. Connolly, Bryan E. Gillis, Susan J. Sullivan   +3 more
doaj   +1 more source

Full-thickness dermal wound regeneration using hypoxia preconditioned blood-derived growth factors: A case series

Organogenesis, 2023
Hard-to-heal wounds can be detrimental to patients’ quality of life. Currently, there is scarcity of therapeutic alternatives to mainstay surgical treatment, which uses the principles of tissue debridement, temporary wound coverage, and subsequent tissue
Hadjipanayi Ektoras, Moog Philipp, Jiang Jun, Dornseifer Ulf, Machens Hans-Günther, Schilling Arndt F   +5 more
doaj   +1 more source

Cotyledon organogenesis [PDF]

Journal of Experimental Botany, 2008
The cotyledon represents one of the bases of classification within the plant kingdom, providing the name-giving difference between dicotyledonous and monocotyledonous plants. It is also a fundamental organ and there have been many reports of cotyledon mutants in many species. The use of these mutants where they have arisen in Arabidopsis has allowed us
openaire   +2 more sources

Inexhaustible hair-cell regeneration in young and aged zebrafish

Biology Open, 2015
Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities.
Filipe Pinto-Teixeira, Oriol Viader-Llargués, Elen Torres-Mejía, Melissa Turan, Estela González-Gualda, Laura Pola-Morell, Hernán López-Schier   +6 more
doaj   +1 more source

Epithelial-mesenchymal feedback signalling during vertebrate organogenesis : genetic analysis of BMP-Gremlin1 antagonistic interactions [PDF]

, 2010
Branching morphogenesis of the metanephric kidney relies on an intricate molecular system that controls a highly regulated developmental program. Metanephric kidney organogenesis involves a complex system of epithelial mesenchymal interactions that ...
Gonçalves, Alexandre
core   +1 more source

Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling

Cell Reports, 2018
Summary: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications.
Junpei Yamamoto, Miyako Udono, Shizuka Miura, Sayaka Sekiya, Atsushi Suzuki   +4 more
doaj   +1 more source

In Vitro Characterization of Porcine Hepatocyte Function

Cell Transplantation, 2000
The clinical consequences of acute liver failure are associated with high mortality. Intensive medical intervention is required to treat the symptoms of liver failure, including coagulopathy, metabolic instability, and encephalopathy. Providing temporary
Paul G. Gregory, Christopher K. Connolly, Mehmet Toner, Susan J. Sullivan   +3 more
doaj   +1 more source

Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells

Nature Communications, 2020
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and ...
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki   +16 more
doaj   +1 more source

BMP Signaling Regulates Bone Morphogenesis in Zebrafish through Promoting Osteoblast Function as Assessed by Their Nitric Oxide Production

Molecules, 2015
Bone morphogenetic proteins (BMPs) control many developmental and physiological processes, including skeleton formation and homeostasis. Previous studies in zebrafish revealed the crucial importance of proper BMP signaling before 48 h post-fertilization (
Thomas Windhausen, Steeve Squifflet, Jörg Renn, Marc Muller   +3 more
doaj   +1 more source

Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]

, 2010
Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
core   +1 more source