Results 51 to 60 of about 66,436 (284)

Role of VEGF in Organogenesis [PDF]

Organogenesis, 2008
The cardiovascular system, consisting of the heart, blood vessels and hematopoietic cells, is the first organ system to develop in vertebrates and is essential for providing oxygen and nutrients to the embryo and adult organs. Work done predominantly using the mouse and zebrafish as model systems has demonstrated that Vascular Endothelial Growth Factor
openaire   +2 more sources

Adaptive Immune Regulation of Mammary Postnatal Organogenesis [PDF]

, 2015
SummaryPostnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive
Kersten, Kelly, Melton, AC, Sheppard, Dean, Werb, Z, Wolf, Yochai, Van den Bijgaart, RJE, Plaks, V, Casbon, Amy-Jo, Melton, Andrew C, Linnemann, Jelena R, van den Bijgaart, Renske JE, Kong, Niwen, Boldajipour, Bijan, Sheppard, D, Krummel, MF, Nguyen, Nguyen H, Plaks, Vicki, Boldajipour, B, Kong, N, Werb, Zena, Linnemann, JR, Nguyen, NH, Casbon, AJ, Wolf, Y, Krummel, Matthew F, Kersten, K   +25 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Nature Communications
Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the ...
Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya, Atsushi Suzuki   +9 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Bone Research
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cell differentiation and tissue repair.
Madysen K. Hunter, Sneha Korlakunta, Neda Vishlaghi, Monisha Mittal, Kyle Cragg, Conan Juan, Chase A. Pagani, Yuxiao Sun, Lindsey Lammlin, Karen Kessell, Dylan Feist, Ji Hae Choi, Meng-Lun Hsieh, Jahnu Saikia, Craig L. Duvall, Heeseog Kang, Andrea I. Alford, Kurt D. Hankenson, Robert J. Tower, Tristan Maerz, Benjamin Levi   +20 more
doaj   +1 more source

Clinical Manufacturing of Regulatory T Cell Products For Adoptive Cell Therapy and Strategies to Improve Therapeutic Efficacy

Organogenesis, 2023
Based on successes in preclinical animal transplant models, adoptive cell therapy (ACT) with regulatory T cells (Tregs) is a promising modality to induce allograft tolerance or reduce the use of immunosuppressive drugs to prevent rejection.
Kassandra J. Baron, Hēth R. Turnquist
doaj   +1 more source

A more improved protocol for in vitro shoot organogenesis in daylily (Hemerocallis sp.) [PDF]

, 2015
Daylily is a crop of landscape, nutritional, and medicinal importance. Despite relative progress, daylily is one of the least explored crops in tissue culture, partly, because of its low responsiveness for in vitro organogenesis.
Acquaah, George, Wu, Ning, Conley, Stephan, Matand, Kanyand   +3 more
core   +1 more source

LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

, 2022
TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC.
Kuprash, Dmitry V., Nedospasov, Sergei A., Dmitry V. Kuprash, Alexei V. Tumanov, Andrey A. Kruglov, Kruglov, Andrey A., Tumanov, Alexei V., Grivennikov, Sergei I., Violetta S. Gogoleva, Sergei A. Nedospasov, Sergei I. Grivennikov, Gogoleva, Violetta S.   +11 more
core   +1 more source