Results 61 to 70 of about 91,856 (332)

Cyborg Organoids: Implantation of Nanoelectronics via Organogenesis for Tissue-Wide Electrophysiology

bioRxiv, 2019
Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies, yet issues arise from invasive, localized implantation of electronics that destructs the well-connected cellular networks ...
Qiang Li, Kewang Nan, Paul Le Floch, Zuwan Lin, Hao Sheng, Thomas S. Blum, Jia Liu   +6 more
semanticscholar   +1 more source

Root organogenesis in Medicago truncatula [PDF]

, 2018
Plant stem cells are contained within niches like the root apical meristem (RAM) which create new cells for organ growth, plant stem cells may also be initiated post-embryogenesis like for the development of lateral roots.
Holmes, Peta Dee
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Nature Communications
Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the ...
Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya, Atsushi Suzuki   +9 more
doaj   +1 more source

Specification of tissue-resident macrophages during organogenesis

Science, 2016
INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation between specialized cell types. Resident macrophages are professional phagocytes that survey their surroundings; eliminate unfit cells, microorganisms, and metabolic waste ...
E. Mass, I. Ballesteros, M. Farlik, F. Halbritter, Patrick Günther, L. Crozet, Christian E. Jacome-Galarza, Kristian Händler, Johanna Klughammer, Yasuhiro Kobayashi, E. Gomez-Perdiguero, J. Schultze, M. Beyer, C. Bock, F. Geissmann   +14 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Bone Research
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cell differentiation and tissue repair.
Madysen K. Hunter, Sneha Korlakunta, Neda Vishlaghi, Monisha Mittal, Kyle Cragg, Conan Juan, Chase A. Pagani, Yuxiao Sun, Lindsey Lammlin, Karen Kessell, Dylan Feist, Ji Hae Choi, Meng-Lun Hsieh, Jahnu Saikia, Craig L. Duvall, Heeseog Kang, Andrea I. Alford, Kurt D. Hankenson, Robert J. Tower, Tristan Maerz, Benjamin Levi   +20 more
doaj   +1 more source

Clinical Manufacturing of Regulatory T Cell Products For Adoptive Cell Therapy and Strategies to Improve Therapeutic Efficacy

Organogenesis, 2023
Based on successes in preclinical animal transplant models, adoptive cell therapy (ACT) with regulatory T cells (Tregs) is a promising modality to induce allograft tolerance or reduce the use of immunosuppressive drugs to prevent rejection.
Kassandra J. Baron, Hēth R. Turnquist
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Thesis Movies - 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'

, 2018
Movies for the doctoral thesis 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'
Munro, David
core   +1 more source