Results 271 to 280 of about 40,189 (319)
The Oximes and Organophosphate Poisoning [PDF]
Archives of Pediatrics & Adolescent Medicine, 1962 Since the insects began fighting back in 1947,1the war against them has demanded an increasingly diversified armamentarium, and the organic phosphate insecticides have played an important part in the battle. Unfortunately, this group of compounds, an outgrowth of wartime investigation of the chemically related nerve gases, are poisonous to man as well ...
Lyman A. Page, Henry L. Verhulst
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Annals of Emergency Medicine, 1987
Organophosphate insecticides have become increasingly popular for agricultural, industrial, and home use and represent a significant potential health risk. We have reviewed the history, pathophysiology, clinical presentation, laboratory findings, differential diagnosis, therapy, and complications of toxic exposure to organophosphates. Promp recognition
J, Tafuri, J, Roberts
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Organophosphate insecticides have become increasingly popular for agricultural, industrial, and home use and represent a significant potential health risk. We have reviewed the history, pathophysiology, clinical presentation, laboratory findings, differential diagnosis, therapy, and complications of toxic exposure to organophosphates. Promp recognition
J, Tafuri, J, Roberts
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The Organophosphate Pesticides [PDF]
Journal of Nutritional & Environmental Medicine, 1995 This article provides a brief historical background to the development of organophosphate (OP) pesticides, and details their chemical structures, synthesis and reactivity. Their toxic effect, through the blocking of acetylcholinesterase, is described, and symptoms of acute and chronic intoxication in humans are outlined.
V. H. Zettel, Jasjit Kang, Neil I. Ward
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Organophosphate polyneuropathy in chicks
Biochemical Pharmacology, 1993Young animals are resistant to organophosphate-induced delayed neuropathy (OPIDP), although biochemical changes on Neuropathy Target Esterase (NTE) caused by neuropathic organophosphorus esters (OP) are similar to those observed in the sensitive hen. We report here that the resistance of chicks to single doses of neuropathic OPs is not absolute because
M. Peraica +3 more
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Pharmacology of organophosphates
Journal of Applied Toxicology, 1994AbstractThe cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described.
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Organophosphates, Serine Esterase Inhibition, and Modeling of Organophosphate Toxicity
Toxicological Sciences, 2004The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be ...
Seth F. Oppenheimer, Janice E. Chambers
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Pharmacology & Therapeutics, 1993
The present review discusses the structure of the anticholinesterase organophosphates (OPs), which are used predominantly as insecticides. OP poisoning can occur in a variety of situations and can be accidental or suicidal. It is common in developing countries.
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The present review discusses the structure of the anticholinesterase organophosphates (OPs), which are used predominantly as insecticides. OP poisoning can occur in a variety of situations and can be accidental or suicidal. It is common in developing countries.
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A Review of Organophosphate Poisoning
Medical Toxicology, 1988Many organophosphate compounds are pesticides widely used for the control of insect vectors. They are not ideal agents because they lack target vector selectivity, and have caused severe toxicity and even death in humans and domestic animals. Their toxicity has been recognised since the 1930s, when they were also developed for use as chemical warfare ...
Neil A. Minton, V. S. G. Murray
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Opsoclonus in Organophosphate Poisoning
Archives of Neurology, 1989Transient opsoclonus was observed in a patient who attempted suicide with the organophosphate insecticide Malathion (diethyl[dimethoxyphosphinothioyl]thiobutanedioate). Several toxins can cause opsoclonus, and these must be considered in its differential diagnosis.
Josanne Aquilina, Patrick Pullicino
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The Management of Organophosphate Intoxication
Southern Medical Journal, 1975This review attempts to reiterate the problem of organophosphate intoxication and the pathophysiologic problems created by these compounds. A discussion of management is included. The case reported of a two-year old child serves to illustrate the tremendously high doses of atropine which may be required to block the acetylcholine accumulated at ...
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