Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP). [PDF]
PLoS ONE, 2017 Aminoalcohols have been addressed as activating buffers for alkaline phosphatase. However, there is no record on the buffer activation regarding organophosphorus hydrolase (OPH).
Dandan Li +5 more
doaj +5 more sources
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides. [PDF]
Toxicology, 2008 Organophosphorus (OP) pesticides poison more than 3,000,000 people every year in the developing world, mostly through intentional self-poisoning. Advances in medical therapy for OP poisoning have lagged, and current treatment is not highly effective with
Bird SB +5 more
europepmc +8 more sources
Kinerja Biosensor Konduktometri Berbasis (Screen Printed Carbon Electrode) SPCE––Kitosan untuk Deteksi Diazinon, Malation, Klorpirifos dan Profenofos [PDF]
Jurnal Kimia Valensi, 2015 The performance of biosensor is based on the hydrolysis reaction of organophosphorus compounds catalyzed by organophosphate hydrolase (OPH), produce H+ and the other ionic species that increase conductance on the surface of electrode.
Nuzulul Kurniawan Isvani +2 more
doaj +4 more sources
Optical Detection of Paraoxon Using Single-Walled Carbon Nanotube Films with Attached Organophosphorus Hydrolase-Expressed Escherichia coli [PDF]
Sensors, 2015 In whole-cell based biosensors, spectrophotometry is one of the most commonly used methods for detecting organophosphates due to its simplicity and reliability.
Intae Kim +4 more
doaj +2 more sources
Simultaneous molecular docking of different ligands to His6-tagged organophosphorus hydrolase as an effective tool for assessing their effect on the enzyme [PDF]
PeerJ, 2019 Background Enzymatic hydrolysis of N-acyl homoserine lactones (AHLs), which are signaling molecules responsible for the development of antibiotic resistance in gram-negative bacteria, is a potential solution to overcoming antibiotic resistance problem ...
Aysel Aslanli, Elena Efremenko
doaj +3 more sources
Computational Modeling Study of the Binding of Aging and Non-Aging Inhibitors with Neuropathy Target Esterase [PDF]
Molecules, 2023 Neuropathy target esterase (NTE) is a serine hydrolase with phospholipase B activity, which is involved in maintaining the homeostasis of phospholipids. It can be inhibited by aging inhibitors such as some organophosphorus (OP) compounds, which leads to ...
Wenxiong Wu, Pan Wang
doaj +2 more sources
Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]
, 2010 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert +15 more
core +20 more sources
Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]
E3S Web of Conferences, 2021 Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin +4 more
doaj +1 more source
Enzyme-armed nanocleaner provides superior detoxification against organophosphorus compounds via a dual-action mechanism [PDF]
Journal of NanobiotechnologyBy inhibiting acetylcholinesterase (AChE) activity, organophosphate compounds (OPs) can quickly cause severe injury to the nervous system and death, making it extremely difficult to rescue victims after OP exposure.
Kang Qin +10 more
doaj +2 more sources
Mathematical Modeling of pH-Based Potentiometric Biosensor Using Akbari-Ganji Method
International Journal of Electrochemical Science, 2022 This study discusses a mathematical model for the steady-state reaction of a pH-based potentiometric biosensor immobilizing organophosphorus hydrolase (OPH).
R. Shanthi +4 more
doaj +1 more source