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A dual enzyme electrochemical assay for the detection of organophosphorus compounds using organophosphorus hydrolase and horseradish peroxidase

Sensors and Actuators B: Chemical, 2011
Abstract Neurotoxic organophosphorus (OP) compounds are commonly used as chemical warfare agents and pesticides. Due to their high toxicity, rapid and sensitive field detection of these compounds has been an ongoing topic of interest. Biosensors made with organophosphate hydrolase enzyme (OPH) are generally designed to either amperometrically detect ...
Asli Sahin   +4 more
openaire   +1 more source

Model of a pH‐Based Potentiometric Biosensor Immobilizing Organophosphorus Hydrolase

Chemical Engineering & Technology, 2006
AbstractA model for predicting the steady‐state response of a pH‐based potentiometric biosensor immobilizing organophosphorus hydrolase (OPH) is developed. The model combines the processes of diffusion and enzymatic reaction in the membrane. Key factors influencing the system response, such as enzyme reaction order, Thiele modulus, and buffer ...
W. Lihong   +3 more
openaire   +1 more source

Mutagenesis of Organophosphorus Hydrolase to Enhance Hydrolysis of the Nerve Agent VX

Biochemical and Biophysical Research Communications, 2000
Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent VX is less than 0.1% relative to its activity against parathion and paraoxon.
S, Gopal   +3 more
openaire   +2 more sources

Discovery of a Ni2+-dependent guanidine hydrolase in bacteria

Nature, 2022
Dietmar Funck   +2 more
exaly  

Biodegradation Of Organophosphorus Nerve Agents by Surface Expressed Organophosphorus Hydrolase

2000
W. Chen   +4 more
openaire   +1 more source

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

Nature Reviews Drug Discovery, 2009
John D Imig, Bruce D Hammock
exaly  

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