Sentinel node biopsy for skin melanoma [PDF]
Background/Aim. Skin melanoma is one of the most malignant diseases with increasing incidence rate. Sentinel node biopsy (SNB) is very important for early detection of metastatic spread. The aim of the study was to analyze the first 40 patients with skin
Kovačević Predrag +4 more
doaj +1 more source
Isocyanide Complexes of Technetium and Rhenium: Steric and Electronic Factors [PDF]
Three aspects of group 7 isocyanide chemistry were considered in this thesis. First, the reactivity of electron-poor isocyanides with facial tricarbonyl starting materials was investigated.
Claude, Guilhem
core +1 more source
{Tc(NO)(Cp)(PPh3)}+ – a novel technetium(I) core [PDF]
Reactions between [TcI(NO)X2(PPh3)2(CH3CN)] complexes (X = Cl, Br) and KCp form the pseudotetrahedral organotechnetium compounds [TcI(NO)(Cp)(PPh3)X]. The halide ligands can readily be replaced by other halides or organometallic ligands giving access to ...
Abram, U., Ackermann, J., Hagenbach, A.
core +1 more source
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance [PDF]
Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells.
Collins, Jeffrey +11 more
core +1 more source
Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors [PDF]
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients.
core +1 more source
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model [PDF]
Accumulation of amyloid-β (Aβ) within extracellular spaces of the brain is a hallmark of Alzheimer disease (AD). In sporadic, late-onset AD, there is little evidence for increased Aβ production, suggesting that decreased elimination from the brain may ...
Bales, Kelly R. +13 more
core +3 more sources
Imaging techniques to study drug transporter function in vivo [PDF]
Transporter systems involved in the permeation of drugs and solutes across biological membranes are recognized as key determinants of pharmacokinetics.
Langer, Oliver +2 more
core +1 more source
Thionitrosyl Complexes of Rhenium and Technetium with PPh3 and Chelating Ligands - Synthesis and Reactivity [PDF]
In contrast to corresponding nitrosyl compounds, thionitrosyl complexes of rhenium and technetium are rare. Synthetic access to the thionitrosyl core is possible by two main approaches: (i) the treatment of corresponding nitrido complexes with S2Cl2 and (
Abram, Ulrich +3 more
core +1 more source
Technetium ‐ The Unknown Center of the Periodic Table
It took 78 years from Mendeleev's proposal of an existence of “eka‐manganese” (1869) until it was finally named as technetium in 1947. Another 78 years have passed since then. A good occasion to pinpoint what we know and what we still don't know of this element in the center of the periodic table.
Erik Strub +9 more
wiley +1 more source
The role of ABC transporters and inflammation in drug-resistant epilepsy [PDF]
This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation.
Weidner, Lora Deuitch
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