Results 1 to 10 of about 3,591,901 (284)

Human organs-on-chips for disease modelling, drug development and personalized medicine

Nature reviews genetics, 2022
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research.
D. Ingber
semanticscholar   +1 more source

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Frontiers in Medicine, 2020
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2).
Xin Zou, Ke Chen, Jiawei Zou, Pei-jun Han, Jie Hao, Ze-Guang Han   +5 more
semanticscholar   +1 more source

Mapping the developing human immune system across organs

bioRxiv, 2022
Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in understanding the ...
Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, R. Botting, Emily Stephenson, J. Engelbert, Z. Tuong, K. Polański, Nadav Yayon, Chuan Xu, Ondrej Suchanek, R. Elmentaite, C. Conde, Peng He, S. Pritchard, M. Miah, C. Moldovan, Alexander S Steemers, M. Prete, J. Marioni, M. Clatworthy, M. Haniffa, S. Teichmann   +25 more
semanticscholar   +1 more source

Inflammatory responses and inflammation-associated diseases in organs

OncoTarget, 2015
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas,
Linlin Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Yinglun Li, Xun Wang, Ling Zhao   +8 more
semanticscholar   +1 more source

Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

Histopathology, 2020
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping pandemic.
T. Menter, J. Haslbauer, R. Nienhold, S. Savic, H. Hopfer, N. Deigendesch, S. Frank, Daniel Turek, N. Willi, H. Pargger, S. Bassetti, J. Leuppi, G. Cathomas, M. Tolnay, K. Mertz, A. Tzankov   +15 more
semanticscholar   +1 more source

Procuring organs for transplantation : a European perspective [PDF]

, 1998
Background: The shortage of organs for transplant In Europe has been considerable for many years. A number of different policies have been implemented in an attempt to address this problem.
Randhawa, Gurch
core   +2 more sources

Nuclear medicine procedures and the evaluation of male sexual organs: a short review [PDF]

, 2008
Sexuality consists of three aspects that are interrelated and inseparable, biological, physiological and social. The biological aspect considers the individual's capability to give and to receive pleasure.
Adenilson de Souza da Fonseca, Bernardo-Filho M., Beutel M. E., Bouchelouche K., Chaffanjon P. C., Choe W., Dennerstein L., Fanti S., Ganjoo K. N., Gerber G., Halac M., Hatzimouratidis H., Jana S., Kevin Carter, Kim C. K., Kolodny R. C., Kotzerke J., Kotzerke J., Kumar V., Lange P. H., Mario Bernardo-Filho, Masters W. H., Orhan I., Perkins A., Perkins A., Ravizzini G., Roivainen A., Ryu J., Saha G., Sebastião David Santos-Filho, Shen Y. Y., Sotiris Missailidis, Stelzner F., Sumich A. L., Timmermans L., Tóth G., Valdés Olmos R. A., Warren G. P., Willan B. D., Zuckier L. S.   +39 more
core   +4 more sources

Organs and organisations: Situating ethics in organ donation after circulatory death in the UK [PDF]

, 2018
Controlled organ donation after circulatory death (DCD) has recently been revived in the UK, as part of attempts to increase organ donation rates.
Academy of Medical Royal Colleges & UK Donation Ethics Committee, Arnold, Bell, Bell, Bernat, British Transplant Society, Brodwin, Brosnan, Button, Callaghan, Cohen, Columb, Cooper, Cooper, Corrigan, Das, De Vita, Department of Health, Department of Health, Dominguez-Gil, Fox, Fox, Gardiner, Gardiner, Gardiner, Giacomini, Hedgecoe, Heimer, Hoeyer, Hoeyer, Hoeyer, Hoeyer, Hoffmaster, Hogle, Hogle, Hosgood, Jasanoff, Jensen, Jensen, Jessie Cooper, Kierans, Kierans, Kierans, Kleinman, Lock, Lock, Lynch, Lynch, Lynch, NHS Blood and Transplant, Ortega-Deballon, Pickersgill, Rapp, Reissman, Scheper-Hughes, Sharp, Smith-Doerr, Sperling, Timmermans, Yea   +59 more
core   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Meiosis: Organizing Microtubule Organizers [PDF]

Current Biology, 2005
During meiosis in fission yeast, the zygote nucleus undergoes microtubule-driven oscillatory movements that ultimately serve to promote genetic recombination. An essential component of this is a meiosis-specific consolidation of microtubule-organizing activity to the the spindle pole body, driven by the novel coiled-coil protein mcp6/hrs1p.
openaire   +2 more sources