Results 1 to 10 of about 2,160,578 (94)

Human organs-on-chips for disease modelling, drug development and personalized medicine

Nature reviews genetics, 2022
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research.
D. Ingber
semanticscholar   +1 more source

Mapping the developing human immune system across organs

bioRxiv, 2022
Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in understanding the ...
Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, R. Botting, Emily Stephenson, J. Engelbert, Z. Tuong, K. Polański, Nadav Yayon, Chuan Xu, Ondrej Suchanek, R. Elmentaite, C. Conde, Peng He, S. Pritchard, M. Miah, C. Moldovan, Alexander S Steemers, M. Prete, J. Marioni, M. Clatworthy, M. Haniffa, S. Teichmann   +25 more
semanticscholar   +1 more source

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Frontiers in Medicine, 2020
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2).
Xin Zou, Ke Chen, Jiawei Zou, Pei-jun Han, Jie Hao, Ze-Guang Han   +5 more
semanticscholar   +1 more source

Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

Histopathology, 2020
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping pandemic.
T. Menter, J. Haslbauer, R. Nienhold, S. Savic, H. Hopfer, N. Deigendesch, S. Frank, Daniel Turek, N. Willi, H. Pargger, S. Bassetti, J. Leuppi, G. Cathomas, M. Tolnay, K. Mertz, A. Tzankov   +15 more
semanticscholar   +1 more source

Inflammatory responses and inflammation-associated diseases in organs

OncoTarget, 2015
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas,
Linlin Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Yinglun Li, Xun Wang, Ling Zhao   +8 more
semanticscholar   +1 more source

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

Science, 2012
Lights, Sound, Images Optical microscopy can readily image thin samples such as cells, but thicker samples, such as tissue, are more difficult to image directly, because of the multiple scattering of light. Wang and Hu (p.
Lihong V. Wang, Song Hu
semanticscholar   +1 more source

3D bioprinting of cells, tissues and organs

Scientific Reports, 2020
3D bioprinting has emerged as a promising new approach for fabricating complex biological constructs in the field of tissue engineering and regenerative medicine.
Madhuri Dey, I. Ozbolat
semanticscholar   +1 more source

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Toxics, 2020
Reproductive organs are essential not only for the life of an individual but also for the survival and development of the species. The response of reproductive organs to toxic substances differs from that of other target organs, and they may serve as an ...
P. Massányi, M. Massányi, R. Madeddu, R. Stawarz, N. Lukáč   +4 more
semanticscholar   +1 more source

Mesenchymal stem cells reside in virtually all post-natal organs and tissues

Journal of Cell Science, 2006
Mesenchymal stem cells (MSCs) are multipotent cells which can give rise to mesenchymal and non-mesenchymal tissues in vitro and in vivo. Whereas in vitro properties such as (trans)differentiation capabilities are well known, there is little information ...
L. Meirelles, P. Chagastelles, N. Nardi
semanticscholar   +1 more source

Effect of COVID-19 on the Organs

Cureus, 2020
The COVID-19 pandemic that first became apparent in Wuhan, China, is now infecting millions all over the world. This is a review of COVID-19's extensive effects on virtually all the organs.
Uday Jain
semanticscholar   +1 more source