Results 41 to 50 of about 14,298 (298)

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

open access: yesAdvanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li   +13 more
wiley   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

open access: yesAdvanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu   +11 more
wiley   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan   +18 more
wiley   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

open access: yesAdvanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang   +15 more
wiley   +1 more source

The orientalist views on the identity of Saracen in Walter Scott’s The Talisman [PDF]

open access: yes, 2022
This study focused on the Orientalist view of the identity of the Saracens shown in the historical novel. The novel chosen as the object of this research is Sir Walter Scott's The Talisman, published in 1825.
Rahman, Muhamad Alief
core   +1 more source

Orientalist Constructions in The Mummy Movie [PDF]

open access: yes, 2010
This thesis is a study about orientalist constructions that are found in The Mummy movie produced by Stephen Sommers. The study specifically discusses the constructions that show about the differences portrayed between the West and the East.
Erlisa Septiasih
core   +1 more source

Localized Hydrogen Release Driven by Mg–Pd Microgalvanic Cells from 3D‐Printed Microneedles Reverses Redox Homeostasis for Psoriasis Treatment

open access: yesAdvanced Science, EarlyView.
A 3D printing microneedle (MP‐MN), loading magnesium‐based micro‐galvanic cells (MP), is designed for improving psoriasis. H2 generated from MP‐MN scavenges ROS and •OH, actives NRF2‐KEAP1 pathway, and decreases inflammation, thereby effectively restoring the oxidative stress homeostasis of psoriatic skin and suppressing the excessive proliferation of ...
Xinyue Shao   +10 more
wiley   +1 more source

Analysis of Plots and Sources of Orientalist Motifs in Russian Porcelain of the 18th–19th Centuries

open access: yesИзвестия Уральского федерального университета. Серия 2: Гуманитарные науки, 2019
This article examines subjects and decorative sources of orientalism in Russian porcelain of the 18th and 19th centuries. It seems important to single out stages of the incremental development of orientalist motifs in Russian porcelain and describe their
Maria Nikolaevna Tsybizova   +1 more
doaj   +1 more source

Orientalist Collections in the Middle East. Taste as Knowledge and Shifting Narratives

open access: yes, 2021
This paper seeks to question the potentialities of private collections of 19th century European art located in the Middle East in the recontextualisation of Orientalism.
Radwan, Nadia Susanne
core  

Fine‐scale genetic structure of the cloud forest tree Ocotea psychotrioides revealed by genome‐wide SNP data

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Recent advances in genomic technologies now enable the reconstruction of evolutionary histories at fine spatial scales, illuminating the complex dynamics that shape biodiversity patterns in naturally discontinuous, archipelago‐like ecosystems such as cloud forests.
Leopoldo Hurtado‐Reveles   +4 more
wiley   +1 more source

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