Results 51 to 60 of about 2,652,563 (309)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
South African Journal of Business Management, 2014 Studies have suggested the positive effect of customer orientation on superior performance. However, these studies have not shown how to covert customer orientation into superior performance through new product development (NPD) activities.
B. C.Y. Lee, F. T.C. Kou
doaj +1 more source
Rethinking Nigeria’s Development Using African Traditional Communication Media for National Orientation [PDF]
, 2018 This paper examines the problem of poor orientation of most Nigerian citizens, especially the rural dwellers, occasioned by the dearth and failure of modern media in rural Nigeria; a phenomenon that has led to a major setback in participatory governance ...
Iyorza, Stanislaus
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An Evaluation of Entrepreneurship Orientation within the LEADER+ program in the European Union [PDF]
Investigaciones Regionales - Journal of Regional Research, 2012 This article deals with the currently widely discussed entrepreneurialorientation (EO) and investigates the roles this concept actually plays withinthe LEADER+ development program and its implementation in three Europeanterritories.
Mario Duarte Canever +2 more
doaj
Residual stress development and evolution in two-phase crystalline material: a discrete dislocation study [PDF]
, 2017 Crystalline materials undergo heterogeneous deformation upon the application of external load, which results in the development of incompatible elastic strains in the material as soon as the load is removed.
Guruprasad, P. J. +4 more
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FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Identifying the Dimensions and Challenges of Using Digital Innovation in Hospitals: A Systematic Review Study [PDF]
Rāhburdhā-yi Mudīriyyat dar Niẓām-i SalāmatBackground: With the advancement of digital technologies, hospitals are increasingly using digital innovations to improve the quality of care, increase productivity, and reduce costs.
Zahra Mirjalili +3 more
doaj
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Manajemen dan Bisnis, 2011 This paper aims to provide understandings on the interrelationships among risk behaviour, learning orientation and market orientation and business relationship development.
Sulhaini .
doaj +1 more source