Results 51 to 60 of about 2,668,543 (308)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Morphology and Orientation Selection of Non-Metallic Inclusions in Electrified Molten Metal [PDF]

, 2017
The effect of electric current on morphology and orientation selection of non-metallic inclusions in molten metal has been investigated using theoretical modelling and numerical calculation.
C. Gatellier, G. Shi, H.V. Atkinson, J. Eshelby, J.M. Gregg, K.M. Wu, L. Klinger, L. Liu, L.F. Zhang, L.F. Zhang, M. Li, M. Suzuki, R. S. Qin, R.I.L. Guthrie, R.S. Qin, R.S. Qin, R.S. Qin, R.S. Qin, R.S. Qin, R.S. Qin, S. Taniguchi, S.A. Decterov, W.B. Dai, W.B. Dai, X.F. Zhang, X.F. Zhang, X.F. Zhang, X.F. Zhang, Y. Dolinsky, Z. C. Zhao, Z.C. Zhao, Z.Y. Deng   +31 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

An Evaluation of Entrepreneurship Orientation within the LEADER+ program in the European Union [PDF]

Investigaciones Regionales - Journal of Regional Research, 2012
This article deals with the currently widely discussed entrepreneurialorientation (EO) and investigates the roles this concept actually plays withinthe LEADER+ development program and its implementation in three Europeanterritories.
Mario Duarte Canever, Alberto Pérez Chueca, Richard Pfeilstetter   +2 more
doaj  

Customer orientation on new product activities and performance from the contract manufacturer’s viewpoint

South African Journal of Business Management, 2014
Studies have suggested the positive effect of customer orientation on superior performance. However, these studies have not shown how to covert customer orientation into superior performance through new product development (NPD) activities.
B. C.Y. Lee, F. T.C. Kou
doaj   +1 more source

Simulating spatial and temporal evolution of multiple wing cracks around faults in crystalline basement rocks [PDF]

, 2007
Fault zones are structurally highly spatially heterogeneous and hence extremely complex. Observations of fluid flow through fault zones over several scales show that this structural complexity is reflected in the hydrogeological properties of faults ...
Anderson, Aydin, Burgmann, Byerlee, Caine, COMSOL, Cruikshank, d'Alessio, d'Alessio, Dalguer, do Nascimento, Du, Du, Evans, Evans, Evans, Evans, Fairley, Galli, Jonathan P. Willson, Lim, Lockner, Losh, Losh, Martel, Martel, Martin, Morrow, Niemeijer, Pollard, Rebecca J. Lunn, Segall, Shen, Tang, Turcotte, Vermilye, Wibberley, Willson, Yamashita, Zoe K. Shipton   +39 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identifying the Dimensions and Challenges of Using Digital Innovation in Hospitals: A Systematic Review Study [PDF]

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat
Background: With the advancement of digital technologies, hospitals are increasingly using digital innovations to improve the quality of care, increase productivity, and reduce costs.
Zahra Mirjalili, Abbas Babainejad, Saeed Sayadi, Hamidreza Mollaei   +3 more
doaj  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source