Results 181 to 190 of about 2,664,283 (267)

Late Holocene environmental history of Dojran, Macedonia: Investigating the interplay of imperial dynamics and climatic change

Journal of Quaternary Science, EarlyView.
ABSTRACT This study presents a high‐resolution, multi‐proxy reconstruction of environmental and land‐use change from Lake Dojran over historical times (last 2500 years), combining pollen, biomarkers, radiocarbon dating, Ottoman taxation records and other historical data.
Alessia Masi, Lucrezia Masci, Georgios C. Liakopoulos, Monica Bini, Alexander Francke, Ilaria Isola, Carlo Ricotta, Laura Sadori, Alexander Sarantis, Sławomir Sprawski, Jakub Sypiański, Irene Tunno, Cristiano Vignola, Bernd Wagner, Giovanni Zanchetta, Adam Izdebski   +15 more
wiley   +1 more source

Six-sigma approach-based visibility graphs. [PDF]

Sci Rep
Ferenczi M, Kummer A, Abonyi J.
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Advanced analysis of formulation parameters governing encapsulation efficiency: drug delivery system. [PDF]

Front Chem
Sumayli A, Alqahtani SS.
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Scalable computation of ultrabubbles in pangenomes by orienting bidirected graphs. [PDF]

Bioinformatics
Harviainen J, Sena F, Moumard C, Politov A, Schmidt S, Tomescu AI.   +5 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Human-like scene graph generation and evaluation. [PDF]

Multimed Tools Appl
Milewski V, Moens MF, Trusca MM.
europepmc   +1 more source

Physics‐Informed Generative Machine Learning for Designing Crack‐Free γ′‐Strengthened Ni‐Based Superalloys for Laser Powder Bed Fusion

Materials Genome Engineering Advances, EarlyView.
This research proposes a physics‐informed generative machine learning framework to design SHA800, a crack‐free γ′‐strengthened nickel‐based superalloy for laser powder bed fusion, achieving a 43% γ′ volume fraction and 587 HV0.2 hardness. ABSTRACT Fabricating γ′‐strengthened nickel‐based superalloys via laser powder bed fusion (LPBF) faces significant ...
Kai Guo, Dongwei Guan, Tao Hu, Yaqing Hou, Xiaoqun Li, Zhongnan Bi, Songzhe Xu, Hao Yu, Wei Xu, Weidong Xuan, Chaoyue Chen, Zhongming Ren   +11 more
wiley   +1 more source

Towards Fixing Vessel Segmentation Breakage: A Systematic Review. [PDF]

J Clin Med
Goffart S, Delingette H, Chierici A, Föllmer B, Bakhouche A, Guo J, Lareyre F, Raffort J.   +7 more
europepmc   +1 more source