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Orientia tsutsugamushi: A life between escapes [PDF]

open access: goldMicrobiologyOpen, 2023
Intracellular bacteria have evolved different strategies to invade, replicate and persist in, and eventually exit from their hosts. The life cycle of the mite-borne, obligate intracellular pathogen Orientia tsutsugamushi (Ot), the causative agent of human scrub typhus, differs in many aspects from that of other members of the Rickettsiales order ...
Lea Fromm, Jonas Mehl, Christian Keller
openalex   +5 more sources

A Rare and Severe Multisystem Cascade of AKI, ARDS, and Septic Shock Leading to Acalculous Cholecystitis in a Young Scrub Typhus Patient: A Case Report From Nepal. [PDF]

open access: yesClin Case Rep
ABSTRACT Scrub typhus, caused by Orientia tsutsugamushi, is an acute febrile illness prevalent in Nepal with a wide spectrum of clinical presentations. Severe forms can lead to multiorgan dysfunction, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), septic shock, and rarely, acalculous cholecystitis.
Kaphle P   +6 more
europepmc   +2 more sources

International Rickettsia Disease Surveillance: An Example of Cooperative Research to Increase Laboratory Capability and Capacity for Risk Assessment of Rickettsial Outbreaks Worldwide

open access: yesFrontiers in Medicine, 2021
Cooperative research that addresses infectious disease surveillance and outbreak investigations relies heavily on availability and effective use of appropriate diagnostic tools, including serological and molecular assays, as exemplified by the current ...
Ju Jiang   +4 more
doaj   +1 more source

Vaccine Design and Vaccination Strategies against Rickettsiae

open access: yesVaccines, 2021
Rickettsioses are febrile, potentially lethal infectious diseases that are a serious health threat, especially in poor income countries. The causative agents are small obligate intracellular bacteria, rickettsiae.
Anke Osterloh
doaj   +1 more source

Development of a New Genus-Specific Quantitative Real-Time PCR Assay for the Diagnosis of Scrub Typhus in South America

open access: yesFrontiers in Medicine, 2022
Scrub typhus is a potentially severe rickettsiosis, caused by Orientia tsutsugamushi in the Asia-Pacific region. Recently, however, two distinct pathogens, “Candidatus Orientia chuto” and “Candidatus Orientia chiloensis”, have been discovered in the ...
Ju Jiang   +10 more
doaj   +1 more source

Eco-epidemiology of rodent-associated trombiculid mites and infection with Orientia spp. in Southern Chile.

open access: yesPLoS Neglected Tropical Diseases, 2023
BackgroundScrub typhus is a potentially severe infection caused by bacteria of the genus Orientia, endemic in Asia-Pacific and recently discovered in southern Chile.
María Carolina Silva de la Fuente   +8 more
doaj   +1 more source

Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China. [PDF]

open access: yesVet Med Sci
Scrub typhus is caused by Orientia tsutsugamushi (OT). In this study, the detection rates of OT in patients and small mammals were 28.13% (18/64) and 13.98% (13/93), respectively. Nine full‐length 56‐kDa TSA genes were identified, comprising four distinct genotypes: Karp‐like (n = 3), Kato‐like (n = 3), Gilliam (n = 2), and TA763 (n = 1). Recombination
Chen L   +9 more
europepmc   +2 more sources

Molecular Description of a Novel Orientia Species Causing Scrub Typhus in Chile

open access: yesEmerging Infectious Diseases, 2020
Scrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted to the Asia Pacific region, scrub typhus has recently been discovered in southern Chile.
Katia Abarca   +7 more
doaj   +1 more source

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