Orientia tsutsugamushi Alters Mitochondrial Function and Selectively Associates with VDAC [PDF]
PathogensOrientia tsutsugamushi is an obligate intracellular alphaproteobacterium and the causative agent of the potentially fatal rickettsiosis, scrub typhus. During infection, O.
Savannah E. Sanchez +4 more
doaj +2 more sources
Transformation and allelic exchange in Orientia tsutsugamushi [PDF]
mBioOrientia tsutsugamushi is a mite-transmitted obligate intracellular bacterium that causes the potentially deadly zoonosis, scrub typhus. The absence of genetic tools for Orientia has limited studies of the microbe-host interactions that underlie scrub ...
Paige E. Allen +3 more
doaj +2 more sources
A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow
Tropical Medicine and Infectious Disease, 2018 Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-transmitted diseases, fraught with a rich historical aspect, particularly as applied to military/wartime situations.
Alice N Maina +2 more
exaly +3 more sources
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis [PDF]
PathogensScrub typhus is an emerging chigger-borne disease caused by the obligate intracellular bacterium Orientia tsutsugamushi. Necroptosis is a form of programmed cell death (PCD) mediated by RIPK3 (serine/threonine kinase receptor interacting protein 3) and ...
Thomas E. Siff +6 more
doaj +2 more sources
Orientia tsutsugamushi Antibodies in Patients with Eschars and Suspected Tickborne Disease [PDF]
Emerging Infectious DiseasesTo investigate local transmission of Orientia tsutsugamushi by chiggers in North Carolina, USA, we tested remnant serum specimens from patients with eschar undergoing testing for suspected tickborne disease.
Haley A. Abernathy +4 more
doaj +2 more sources
Utility of next-generation sequencing for the etiological diagnosis of Orientia tsutsugamushi infection [PDF]
Infectious MedicineBackground: Scrub typhus, an acute febrile disease caused by Orientia tsutsugamushi, is transmitted to humans through infected chigger mites. We present a case of scrub typhus in a previously healthy man from Shandong Province diagnosed using next ...
Nannan Xu +4 more
doaj +2 more sources
Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche [PDF]
Nature CommunicationsInfections by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that ultimately eliminate the damaged cell and hence the microbial niche.
Paige E. Allen +3 more
doaj +2 more sources
Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression [PDF]
Nature CommunicationsHow intracellular bacteria subvert the major histocompatibility complex (MHC) class I pathway is poorly understood. Here, we show that the obligate intracellular bacterium Orientia tsutsugamushi uses its effector protein, Ank5, to inhibit nuclear ...
Haley E. Adcox +6 more
doaj +2 more sources
Frontiers in Medicine, 2022 Scrub typhus is a potentially severe rickettsiosis, caused by Orientia tsutsugamushi in the Asia-Pacific region. Recently, however, two distinct pathogens, “Candidatus Orientia chuto” and “Candidatus Orientia chiloensis”, have been discovered in the ...
Ju Jiang +10 more
doaj +1 more source
Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner. [PDF]
PLoS ONE, 2012 Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium, which escapes from the endo/phagosome and replicates in the host cytoplasm. O.
Jung-Eun Koo +4 more
doaj +1 more source