Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner. [PDF]
PLoS ONE, 2012 Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium, which escapes from the endo/phagosome and replicates in the host cytoplasm. O.
Jung-Eun Koo +4 more
doaj +1 more source
Hematogenously disseminated Orientia tsutsugamushi-infected murine model of scrub typhus [corrected]. [PDF]
PLoS Neglected Tropical Diseases, 2014 Orientia tsutsugamushi, the etiologic agent of scrub typhus, is a mite-borne rickettsia transmitted by the parasitic larval stage of trombiculid mites. Approximately one-third of the world's population is at risk of infection with Orientia tsutsugamushi,
Thomas R Shelite +8 more
doaj +1 more source
Shotgun proteomics of Orientia tsutsugamushi [PDF]
Clinical Microbiology and Infection, 2009 Orientia tsutsugamushi is one of the obligate intracellular bacteria, and causes Tsutsugamushi disease (scrub typhus). The whole genome sequence of Boryong strain revealed some characteristics of this bacterium, such as a type IV secretion system, many histidine kinases, SpoT, Tra, and ankyrin repeatand tetratricopeptide repeat (TPR)-containing ...
Ogawa, M. +7 more
openaire +2 more sources
Analysis of Orientia tsutsugamushi promoter activity [PDF]
Pathogens and Disease, 2021 ABSTRACT Orientia tsutsugamushi is an obligate intracellular bacterium that causes scrub typhus, a potentially fatal rickettsiosis, and for which no genetic tools exist. Critical to addressing this technical gap is to identify promoters for driving expression of antibiotic resistance and fluorescence reporter genes in O.
Jason R Hunt, Jason A Carlyon
openaire +2 more sources
Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China. [PDF]
Vet Med SciScrub typhus is caused by Orientia tsutsugamushi (OT). In this study, the detection rates of OT in patients and small mammals were 28.13% (18/64) and 13.98% (13/93), respectively. Nine full‐length 56‐kDa TSA genes were identified, comprising four distinct genotypes: Karp‐like (n = 3), Kato‐like (n = 3), Gilliam (n = 2), and TA763 (n = 1). Recombination
Chen L +9 more
europepmc +2 more sources
Classification of Rickettsia tsutsugamushi in a New Genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. [PDF]
International Journal of Systematic Bacteriology, 1995 Recent studies of Rickettsia tsutsugamushi have demonstrated clearly the phenotypic and genotypic differences between this microorganism and other species belonging to the genus Rickettsia. Therefore, classification of R. tsutsugamushi in a new genus, Orientia gen. nov., is proposed.
A, Tamura +3 more
openaire +2 more sources
Indoor and Outdoor Rodent Hosts of Orientia tsutsugamushi, Shandong Province, China
Emerging Infectious Diseases, 2021 During December 2012–July 2016, we tested small indoor and outdoor mammals in Qingdao, China, for Orientia tsutsugamushi infection. We found that outdoor Apodemus agrarius mice, Cricetulus barabensis hamsters, and Niviventer confucianus rats, as well as ...
Fei Li +5 more
doaj +1 more source
A case of Henoch-Schönlein purpura associated with scrub typhus
BMC Infectious Diseases, 2020 Background Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi.
Jae Hyoung Im +7 more
doaj +1 more source
Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report
International Journal of Infectious Diseases, 2020 Background: Scrub typhus is caused by Orientia tsutsugamushi. Clinical manifestations include fever, rash, eschar at the bite site, and other non-specific flu-like symptoms.
Jing Wu, Yumeng Wu, Man Huang
doaj +1 more source
Persistence of Orientia tsutsugamushi in Humans
Journal of Korean Medical Science, 2012 We investigated the persistence of viable Orientia tsutsugamushi in patients who had recovered from scrub typhus. Blood specimens were available from six patients with scrub typhus who were at 1 to 18 months after the onset of the illness. The EDTA-treated blood specimens were inoculated into ECV304 cells, and cultures were maintained for 7 months ...
Chung, Moon-Hyun +4 more
openaire +2 more sources