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Orientia tsutsugamushi: A life between escapes. [PDF]

Microbiologyopen, 2023
Intracellular bacteria have evolved different strategies to invade, replicate and persist in, and eventually exit from their hosts. The life cycle of the mite-borne, obligate intracellular pathogen Orientia tsutsugamushi (Ot), the causative agent of human scrub typhus, differs in many aspects from that of other members of the Rickettsiales order ...
Fromm L, Mehl J, Keller C.
europepmc   +7 more sources

Approaches to vaccines against Orientia tsutsugamushi [PDF]

Frontiers in Cellular and Infection Microbiology, 2013
Scrub typhus is a severe mite-borne infection caused by Orientia tsutsugamushi, an obligately intracellular bacterium closely related to Rickettsia. The disease explains a substantial proportion of acute undifferentiated febrile cases that require hospitalization in rural areas of Asia, the North of Australia, and many islands of the Pacific Ocean ...
Gustavo Valbuena, David H Walker, Walker David H   +2 more
exaly   +5 more sources

Utility of next-generation sequencing for the etiological diagnosis of Orientia tsutsugamushi infection [PDF]

Infectious Medicine
Background: Scrub typhus, an acute febrile disease caused by Orientia tsutsugamushi, is transmitted to humans through infected chigger mites. We present a case of scrub typhus in a previously healthy man from Shandong Province diagnosed using next ...
Nannan Xu, Lintao Sai, Gang Wang, Gregory A. Dasch, Marina E. Eremeeva   +4 more
doaj   +3 more sources

Orientia tsutsugamushi Alters Mitochondrial Function and Selectively Associates with VDAC [PDF]

Pathogens
Orientia tsutsugamushi is an obligate intracellular alphaproteobacterium and the causative agent of the potentially fatal rickettsiosis, scrub typhus. During infection, O.
Savannah E. Sanchez, Travis J. Chiarelli, John S. Billingsley, Richard T. Marconi, Jason A. Carlyon   +4 more
doaj   +2 more sources

Survival and Growth of Orientia tsutsugamushi in Conventional Hemocultures [PDF]

Emerging Infectious Diseases, 2016
Orientia tsutsugamushi, which requires specialized facilities for culture, is a substantial cause of disease in Asia. We demonstrate that O. tsutsugamushi numbers increased for up to 5 days in conventional hemocultures.
Sabine Dittrich, Elizabeth Card, Weerawat Phuklia, Williams E. Rudgard, Joy Silousok, Phonelavanh Phoumin, Latsaniphone Bouthasavong, Sarah Azarian, Viengmon Davong, David A.B. Dance, Manivanh Vongsouvath, Rattanaphone Phetsouvanh, Paul N. Newton   +12 more
doaj   +5 more sources

A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow

Tropical Medicine and Infectious Disease, 2018
Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-transmitted diseases, fraught with a rich historical aspect, particularly as applied to military/wartime situations.
Daryl J Kelly, Alice N Maina, Ju Jiang
exaly   +3 more sources

Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis [PDF]

Pathogens
Scrub typhus is an emerging chigger-borne disease caused by the obligate intracellular bacterium Orientia tsutsugamushi. Necroptosis is a form of programmed cell death (PCD) mediated by RIPK3 (serine/threonine kinase receptor interacting protein 3) and ...
Thomas E. Siff, Paige E. Allen, David L. Armistead, Jason R. Hunt, Steven J. Rolland, Hervé Agaisse, Jason A. Carlyon   +6 more
doaj   +2 more sources

Orientia tsutsugamushi Antibodies in Patients with Eschars and Suspected Tickborne Disease [PDF]

Emerging Infectious Diseases
To investigate local transmission of Orientia tsutsugamushi by chiggers in North Carolina, USA, we tested remnant serum specimens from patients with eschar undergoing testing for suspected tickborne disease.
Haley A. Abernathy, Lauryn Ursery, Brooke A. Merdjane, Dana A. Giandomenico, Ross M. Boyce   +4 more
doaj   +2 more sources

Genetic Characterization of Orientia tsutsugamushi, Bhutan, 2015. [PDF]

Emerg Infect Dis
We performed molecular characterization of Orientia tsutsugamushi on DNA sequences from 5 patients from Bhutan with scrub typhus. In the 56 kDa gene, all isolates aligned with those from other Asia countries, including Nepal, India, Thailand, and Taiwan. High serum IgM titers correlated with PCR positivity in acutely ill patients.
Tshokey T, Stenos J, Tadepalli M, Nguyen C, Graves SR.   +4 more
europepmc   +3 more sources

Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche [PDF]

Nature Communications
Infections by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that ultimately eliminate the damaged cell and hence the microbial niche.
Paige E. Allen, David L. Armistead, Svetlana Blinova, Jason A. Carlyon   +3 more
doaj   +2 more sources