Results 51 to 60 of about 7,496 (242)

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

Journal of Microscopy, Volume 301, Issue 2, Page 187-205, February 2026.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North, Ved P. Sharma, Christina Pyrgaki, John Lim S.Y., Sharanjeet Atwal, Kittirat Saharat, Graham D. Wright, Jeanne Salje   +7 more
wiley   +1 more source

Endemic Scrub Typhus–like Illness, Chile

Emerging Infectious Diseases, 2011
We report a case of scrub typhus in a 54-year-old man who was bitten by several terrestrial leeches during a trip to Chiloé Island in southern Chile in 2006.
M. Elvira Balcells, Ricardo Rabagliati, Patricia García, Helena Poggi, David Oddó, Marcela Concha, Katia Abarca, Ju Jiang, Daryl J. Kelly, Allen L. Richards, Paul A. Fuerst   +10 more
doaj   +1 more source

Dissemination of Orientia tsutsugamushi, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse

Frontiers in Immunology, 2018
Scrub typhus is caused by Orientia tsutsugamushi, an obligated intracellular bacterium that affects over one million people per year. Several mouse models have been used to study its pathogenesis, disease immunology, and for testing vaccine candidates ...
Le Jiang, Erin K. Morris, Rodrigo Aguilera-Olvera, Zhiwen Zhang, Teik-Chye Chan, Soumya Shashikumar, Chien-Chung Chao, Chien-Chung Chao, Sofia A. Casares, Sofia A. Casares, Wei-Mei Ching, Wei-Mei Ching   +11 more
doaj   +1 more source

Neglected scrub typhus: An updated review with a focus on omics technologies

Asian Pacific Journal of Tropical Medicine, 2022
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites ...
Dixit Sharma, Ankita Sharma, Birbal Singh, Sunil Kumar, Shailender Kumar Verma   +4 more
doaj   +1 more source

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM, Cautivo, Kelly M, Deshpande, Aniruddh V, Foster, Paul S, Hansbro, Philip M, Jiang, Simon H, Loering, Svenja, McKenzie, Andrew NJ, Molofsky, Ari B, Starkey, Malcolm R   +9 more
core   +4 more sources

Persistence of Orientia tsutsugamushi in Humans

Journal of Korean Medical Science, 2012
We investigated the persistence of viable Orientia tsutsugamushi in patients who had recovered from scrub typhus. Blood specimens were available from six patients with scrub typhus who were at 1 to 18 months after the onset of the illness. The EDTA-treated blood specimens were inoculated into ECV304 cells, and cultures were maintained for 7 months ...
Chung, Moon-Hyun, Lee, Jin-Soo, Baek, Ji-hyeon, Kim, Mijeong, Kang, Jae-Seung   +4 more
openaire   +2 more sources

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2

BMC Infectious Diseases, 2019
Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp. Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding ...
Stuart D. Blacksell, Matthew T. Robinson, Paul N. Newton, Soiratchaneekorn Ruanchaimun, Jeanne Salje, Tri Wangrangsimakul, Matthew D. Wegner, Mohammad Yazid Abdad, Allan M. Bennett, Allen L. Richards, John Stenos, Nicholas P. J. Day   +11 more
doaj   +1 more source

Identification of trombiculid mites (Acari: Trombiculidae) on rodents from Chiloé Island and molecular evidence of infection with Orientia species.

PLoS Neglected Tropical Diseases, 2020
BACKGROUND:Scrub typhus is an emerging vector-borne zoonosis, caused by Orientia spp. and transmitted by larvae of trombiculid mites, called chiggers. It mainly occurs within a region of the Asia-Pacific called the tsutsugamushi triangle, where rodents ...
Gerardo Acosta-Jamett, Constanza Martínez-Valdebenito, Esperanza Beltrami, María Carolina Silva-de La Fuente, Ju Jiang, Allen L Richards, Thomas Weitzel, Katia Abarca   +7 more
doaj   +1 more source

Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification [PDF]

, 2012
BACKGROUND: Spotted fever caused spotted fever group rickettsiae (SFGR) is prevalent throughout China. In this study, we describe a rapid, simple, and sensitive loop-mediated isothermal amplification (LAMP) assay targeting the ompB gene of spotted fever ...
Guiqiang Wang, Lei Pan, Lijuan Zhang, Qinghui Liu   +3 more
core   +1 more source