Results 131 to 140 of about 5,350,711 (346)

Pharmacology [PDF]

open access: yes, 2011
The popular trope which depicts the origin of life on earth as emerging from a ?chemical soup? continues to have an enduring hold over the imagination. Of course, whether this ?soup?
Boothroyd, Dave
core  

The ecology-evolution continuum and the origin of life. [PDF]

open access: yesJ R Soc Interface, 2023
Baum DA   +5 more
europepmc   +1 more source

The Chirality Of Life: From Phase Transitions To Astrobiology [PDF]

open access: yesarXiv, 2008
The search for life elsewhere in the universe is a pivotal question in modern science. However, to address whether life is common in the universe we must first understand the likelihood of abiogenesis by studying the origin of life on Earth. A key missing piece is the origin of biomolecular homochirality: permeating almost every life-form on Earth is ...
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

The origin and early evolution of life in chemical complexity space [PDF]

open access: yesarXiv, 2018
Life can be viewed as a localized chemical system that sits on, or in the basin of attraction of, a metastable dynamical attractor state that remains out of equilibrium with the environment. Such a view of life allows that new living states can arise through chance changes in local chemical concentration (=mutations) that move points in space into the ...
arxiv  

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

The caveats in the diagnosis of anomalous origin of left coronary artery from pulmonary artery (ALCAPA) [PDF]

open access: yes, 2010
Anomalous origin of left coronary artery from pulmonary artery (ALCAPA) is an infrequent, well described, but important anomaly of the coronary origin. Early diagnosis and prompt surgical treatment of the disease can be life saving. However, there are
Kothari, Shyam S., Varghese, M.J.
core   +1 more source

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