Results 141 to 150 of about 860,302 (306)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Aperture (On the Origin of Human Life) [PDF]
, 1979 A newsletter with University of Lethbridge campus news.THE UNIVERSITY OF LETHBRIDGE APERTURE ON THE ORIGIN OF HUMAN LIFE People may have heard of science and religions on Evolution- Genesis many times and might even balk at a prospect of rehashing the ...
University of Lethbridge
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The Exceptional Solubility of Cyclic Trimetaphosphate in the Presence of Mg2+ and Ca2+
LifeStudying the origin of life requires identifying chemical and physical processes that could have supported early self-replicating and evolving molecular systems.
Megan G. Bachant, Ulrich F. Müller
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Chemical evolution and the origin of life / [PDF]
, 1971 Proceedings of the International conference on the origin of life"Sole distributors for the U.S.A. and Canada: American Elsevier Publishing Company ...
Ponnamperuma, Cyril Andrew,1923-1994(viaf)73918045 +2 more
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Proto-Neurons from Abiotic Polypeptides
EncyclopediaTo understand the origins of life, we must first gain a grasp of the unresolved emergence of the first informational polymers and cell-like assemblies that developed into living systems. Heating amino acid mixtures to their boiling point produces thermal
Panagiotis Mougkogiannis +1 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The ecology-evolution continuum and the origin of life. [PDF]
J R Soc Interface, 2023 Baum DA +5 more
europepmc +1 more source