Results 171 to 180 of about 10,156,255 (270)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The relationship between 1,25(OH)₂D₃ levels and interleukin-32 and vascular endothelial growth factor levels in endometriosis cyst tissue: An original article. [PDF]

SAGE Open Med
Ismail M, Syam HH, Ritonga MA, Rachmawati A, Permadi W, Anwar R, Widad S.   +6 more
europepmc   +1 more source

Letter to the Editor on the original article "Lack of changes in preterm delivery and stillbirths during COVID-19 lockdown in a European region" by Juan Arnaez. [PDF]

Eur J Pediatr, 2021
Vimalesvaran S, Shetty M, Khashu M.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Annals Academy of Medicine Risk Adjustment for Comparing Health Outcomes-Yew Yoong Ding Susceptibility Genes in IgA nephropathy-Woo Keng Thye et al [PDF]

, 2020
Original Article
core  

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Original article: adolescent dietary patterns derived using principal component analysis and neuropsychological functions: a cross-sectional analysis of Walnuts Smart Snack cohort. [PDF]

Eur Child Adolesc Psychiatry
Ayala-Aldana N, Pinar-Martí A, Ruiz-Rivera M, Fernández-Barrés S, Romaguera D, Casanova-Mollà J, Solà-Valls N, Julvez J.   +7 more
europepmc   +1 more source

"Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience", a retrospective study-original article. [PDF]

Ann Med Surg (Lond), 2021
Chachar AZK, Khan KA, Iqbal J, Shahid AH, Asif M, Fatima SA, Khan AA, Younis BB.   +7 more
europepmc   +1 more source

Original Article: Highly conserved cross‐reactive CD4+ T‐cell HA‐epitopes of seasonal and the 2009 pandemic influenza viruses [PDF]

, 2010
Venkata R. Duvvuri, Seyed M. Moghadas, Hongbin Guo, Bhargavi Duvvuri, Jane M. Heffernan, David N. Fisman, Gillian E. Wu, Jian Wu   +7 more
openalex   +1 more source