Results 41 to 50 of about 454,489 (283)

Hipertensión y complicaciones cardiovasculares, artículos originales.

open access: yesREV SEN
La hipertensión arterial en pacientes con enfermedad renal crónica tiene un comportamiento paradójico comparado con la población general. Los mejores resultados en supervivencia se han presentado en pacientes con hipertensión arterial sistólica mayor a ...
SLANH
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

El originalismo de intenciones originales:

open access: yesRevista de Derecho (Coquimbo), 2016
En este trabajo me propongo abordar la teoría que se dio en llamar: “originalismo de intenciones originales”, es decir, la teoría contemporánea de la interpretación constitucional que mantiene el significado de las normas constitucionales remite a lo ...
Luciano Laise
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

La imaginación al poder [PDF]

open access: yes, 1994
Se espera que los intelectuales de la sociedad den soluciones originales y que dejen atrás caducos ...
García Verduch, Antonio
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Uso potencial de cruzas simples emparentadas de ciclo vegetativo intermedio para regiones subtropicales de México.

open access: yesAgronomía Mesoamericana, 2016
El programa de maíz del Campo Experimental Bajío, perteneciente al Instituto Nacional de Investigadores Forestalesy Agropecuariaas (INIF AP), situado en el Estado de Guanajuato, México durante 1994 y 1995 se evaluaron ensayos de rendimiento que contenían
Ernesto Preciado, Arturo Terron
doaj   +1 more source

Dades de recepció i acceptació d’originals / Datos de recepción y aceptación de originales / Data on reception and acceptance of originals [PDF]

open access: yes, 2017
Dades de recepció i acceptació d’originals / Datos de recepción y aceptación de originales / Data on reception and acceptance of ...
,, Trípodos, Revista
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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