Results 61 to 70 of about 50,064 (277)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Revisión del género Helvella (Ascomycota: Fungi) en México

Revista Mexicana de Biodiversidad, 2013
Se presenta una revisión taxonómica de las especies de Helvella citadas para México. De las 29 especies y 1 variedad previamente citadas para el país, se corroboró la presencia de 18 especies, las otras 11 y la variedad son dudosas o no corresponden con ...
Fidel Landeros Jaime, Laura Guzmán Dávalos   +1 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Originales y copias

, 1922
Papel. - Artículo titulado ORIGINALES Y COPIAS publicado en CARAS Y CARETAS (BUENOS AIRES). - Procedencia: fondo Miguel de Unamuno.
Unamuno, Miguel de, 1864-1936
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Las fuentes de las diferentes historias originales del Chimalpahin

, 1977
Romero Galván José Rubén. Las fuentes de las diferentes historias originales del Chimalpahin. In: Journal de la Société des Américanistes. Tome 64, 1977. pp.
Romero Galván, José Rubén
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Contre la protection des idées originales par le droit d'auteur

, 2009
More Karim. Contre la protection des idées originales par le droit d'auteur. In: Revue juridique de l'Ouest, 2009-3. pp.
More, Karim
core   +1 more source

Desarrollo y validación de un método de valoración para Oseltamivir en capsulas y polvo para suspensión oral [PDF]

Revista Argentina de Salud Pública, 2011
La Organización Mundial de la Salud (OMS) declaró la pandemia de gripe A H1N1 en 2009. La autoridad sanitaria argentina promovió el desarrollo y validación de un método de control de calidad de productos farmacéuticos que contenían oseltamivir como ...
Melina, Assalone , Raquel, Santisteban, Christian, Rabahia,, Jessica , Bertinatto , Leandro, Ithuralde, Olga, Gruc , Alicia , Larrinaga , Marta , Spinetto, Carlos, Chiale   +8 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source