Results 61 to 70 of about 454,489 (283)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Páginas originales : (memorias de un maestro de escuela) [PDF]
, 1886 Copia digital. Valladolid : Junta de Castilla y León.
Almudévar y Castillo, Valero, 1843-1915 +1 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
La tradición de tener animales en los pueblos originarios de Iztapalapa
Iztapalapa, 2018 En los pueblos originales de la delegación Iztapalapa la presencia de animales domésticos y fauna está estrechamente vinculada con las actividades agropecuarias desde tiempos prehispánicos. Los animales están asociados con diversas actividades sociales y
Hermenegildo Losada Custardoy +3 more
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Difusión y conservación del libro antiguo: exposición de originales [PDF]
, 2008 Se trata el tema de la difusión del libro antiguo desde una perspectiva de la conservación de los originales. Se repasan conceptos relativos a exposiciones, normativas y posibilidades ofrecidas por los nuevos entornos virtuales como por ejemplo Second ...
Martinez-Avila, Daniel +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2013 This Deliverable gives a detailed description of the comprehensive training programme and of the open educational content that the University of Padua has accomplished up to now for the project "Linked Heritage: Coordination of standard and technologies ...
Bianchi , Elena +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Comportamiento de los contrastes ADF, PP y KPSS al trabajar con series ajustadas de estacionalidad [PDF]
, 2001 En este trabajo se analiza el comportamiento de los tests de raíces unitarias cuando se utilizan los componentes ciclo-tendencia obtenidos a partir de procedimientos de extracción de señales en lugar de utilizar las series originales.
Barrio Castro, Tomás del +2 more
core +1 more source