Results 71 to 80 of about 50,064 (277)

La tradición de tener animales en los pueblos originarios de Iztapalapa

open access: yesIztapalapa, 2018
En los pueblos originales de la delegación Iztapalapa la presencia de animales domésticos y fauna está estrechamente vinculada con las actividades agropecuarias desde tiempos prehispánicos. Los animales están asociados con diversas actividades sociales y
Hermenegildo Losada Custardoy   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

ALESSANDRINO. En busca de los valores originales de los valores originales de la trama urbana

open access: yes, 2016
Il quartiere Alessandrino: alla ricerca dei valori originali del tessuto urbano scomparso.Alessandrino: en busca de los valores originales de la trama urbana ...
Francesca Geremia   +2 more
core  

Dépôt de lettres originales à la Bibliothèque de l'Institut

open access: yes, 1872
Delisle Léopold. Dépôt de lettres originales à la Bibliothèque de l'Institut. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 16ᵉ année, 1872. pp.
Léopold Delisle, Delisle, Léopold
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Les œuvres originales de Galilée dans quelques grandes bibliothèques parisiennes

open access: yes, 1965
Taton Rene. Les œuvres originales de Galilée dans quelques grandes bibliothèques parisiennes. In: Revue d'histoire des sciences et de leurs applications, tome 18, n°2, 1965. pp.
Taton, René
core   +1 more source

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