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Production technologies and formulation strategies in development of orodispersible tablets (ODTs) [PDF]

Makedonsko Farmacevtski Bilten
One of the new ways of drug delivery that is being developed more and more often recently is orodispersible tablets (ODTs), also known as orally disintegrating tablets, rapidly dissolving tablets and fast-dissolving tablets.
Stevche Acevski, Angela Mircevska, Marija Glavas Dodov   +2 more
doaj   +1 more source

Nanomedicine Therapies for Pediatric Diseases

WIREs Nanomedicine and Nanobiotechnology, Volume 16, Issue 5, September/October 2024.
This review highlights the unique challenges in pediatric drug therapy and emphasizes the potential of nanomedicines in addressing these challenges, detailing their properties, Food and Drug Administration‐approved applications, and preclinical studies that may translate to clinical practice in treating pediatric diseases.
Shicheng Yang, Kushi Aggarwal, Jillian Jurczyszak, Needa Brown, Srinivas Sridhar   +4 more
wiley   +1 more source

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

Pharmaceutics, 2018
Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications.
Nihad Al-Hashimi, Nazish Begg, Raid G. Alany, Hany Hassanin, Amr Elshaer   +4 more
doaj   +1 more source

Formulation and Optimization of Oral Fast Dissolving

Iraqi Journal of Pharmaceutical Sciences, 2017
Prochloperazine maleate (PCM) is one of the most prescribed phenothiazine. The purpose of the present research was to develop fast dissolving tablets of PCM with β-cyclodextrin inclusion complex. Tablets prepared  by wet granulation with sublimation and
Dua'a K. Ahmed, Balkis A. Kamal
doaj  

Orodispersible Dosage Forms with Rhinacanthin-Rich Extract as a Convenient Formulation Dedicated to Pediatric Patients

Pharmaceuticals
Rhinacanthins, derived from Rhinacanthus nasutus, widely used in traditional medicine, exhibit antifungal, anticancer, antiviral, antibacterial, and antiplatelet aggregation effects.
Thongtham Suksawat, Witold Brniak, Ewelina Łyszczarz, Małgorzata Wesoły, Patrycja Ciosek-Skibińska, Aleksander Mendyk   +5 more
doaj   +1 more source

Drug dissolution and transit in a heterogenous gastric chyme after fed administration: Semi-mechanistic modeling and simulations for an immediate-release and orodispersible tablets containing a poorly soluble drug.

European journal of pharmaceutics and biopharmaceutics
Mathematical models that treat the fed stomach content as a uniform entity emptied with a constant rate may not suffice to explain pharmacokinetic profiles recorded in clinical trials.
D. Danielak, M. Gajda, Tomasz Bołtromiuk, Katarzyna Sulikowska, Bartłomiej Kubiak, Michał Romański   +5 more
semanticscholar   +1 more source

The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity

Saudi Pharmaceutical Journal, 2017
The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized.
Sonia Iurian, Elena Dinte, Cristina Iuga, Cătălina Bogdan, Iuliana Spiridon, Lucian Barbu-Tudoran, Andreea Bodoki, Ioan Tomuţă, Sorin E. Leucuţa   +8 more
doaj   +1 more source

Effectiveness of treatment with budesonide orodispersible tablets in 76 patients with eosinophilic oesophagitis – real-life experience from the population-based DanEoE cohort

Scandinavian Journal of Gastroenterology
Background Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disease. In Denmark, the budesonide orodispersible tablet (BOT) is recommended as a second-line treatment for proton pump inhibitor-refractory EoE patients.
L. T. Frandsen, D. Melgaard, S. K. Hansen, K. Mørk, A. Krarup   +4 more
semanticscholar   +1 more source

An algorithm for the diagnosis and treatment of eosinophilic esophagitis in adults, 2024 update

Allergy, Volume 79, Issue 12, Page 3546-3549, December 2024.
Marc Pfefferlé, Thomas Greuter
wiley   +1 more source

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

Acta Pharmaceutica, 2017
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM ...
Sipos Emese, Oltean Andrea Ramona, Szabó Zoltán-István, Rédai Emőke-Margit, Nagy Gabriella Dónáth   +4 more
doaj   +1 more source